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- 抗原 See all TGFBR1 抗体
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TGFBR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody detects endogenous levels of TGFβ RI protein.(region surrounding Glu161)
- 纯化方法
- Affinity Chromatography
- Top Product
- Discover our top product TGFBR1 Primary Antibody
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- 应用备注
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ELISA: 1: 5000approx. 1: 10000. Western Blot: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression." in: Frontiers in pharmacology, Vol. 8, pp. 779, (2017) (PubMed).
: "Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway." in: International journal of molecular medicine, Vol. 32, Issue 1, pp. 151-7, (2013) (PubMed).
: "Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa." in: Human reproduction (Oxford, England), Vol. 27, Issue 7, pp. 1985-93, (2012) (PubMed).
: "The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 18700-9, (2012) (PubMed).
: "Nitric oxide enhances melanogenesis of alpaca skin melanocytes in vitro by activating the MITF phosphorylation." in: Molecular and cellular biochemistry, Vol. 352, Issue 1-2, pp. 255-60, (2011) (PubMed).
: "Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4291-301, (2010) (PubMed).
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The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression." in: Frontiers in pharmacology, Vol. 8, pp. 779, (2017) (PubMed).
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- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- TGFBR1 / ALK-5 (TGFBR1 产品)
- 别名
- AAT5 antibody, ACVRLK4 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, SKR4 antibody, TGFR-1 antibody, aat5 antibody, acvrlk4 antibody, alk-5 antibody, alk5 antibody, lds1a antibody, lds2a antibody, skr4 antibody, tgfr-1 antibody, TGFBR1 antibody, x-trr1 antibody, AU017191 antibody, Alk-5 antibody, TbetaR-I antibody, TbetaRI antibody, Alk5 antibody, Skr4 antibody, Tgfr-1 antibody, tbetaR-I antibody, tgfbr1 antibody, zgc:123263 antibody, transforming growth factor beta receptor 1 antibody, transforming growth factor beta receptor I antibody, transforming growth factor beta receptor I S homeolog antibody, transforming growth factor, beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, transforming growth factor, beta receptor 1 a antibody, TGFBR1 antibody, tgfbr1 antibody, tgfbr1.S antibody, Tgfbr1 antibody, tgfbr1a antibody
- 背景
- Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.Synonyms: ALK5, Activin receptor-like kinase 5, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type-1, TGF-beta type I receptor, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I
- 分子量
- approx. 55 kDa
- 基因ID
- 7046
- NCBI登录号
- NP_001124388
- UniProt
- P36897
- 途径
- Growth Factor Binding
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