TGFBR1 抗体
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北京 101111
Quick Overview for TGFBR1 抗体 (ABIN317892)
抗原
See all TGFBR1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of TGFβ RI protein.(region surrounding Glu161)
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纯化方法
- Affinity Chromatography
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anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) antibody
TGFBR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 50-63) antibodyVerified TGFBR1 适用: 人, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (pSer165) antibodyTGFBR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 157-244) antibodyTGFBR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-124) antibodyTGFBR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 134-163) antibodyTGFBR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal RB03530 unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 162-403) antibodyTGFBR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (Tyr159) antibodyTGFBR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) antibodyTGFBR1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 145-172) antibodyTGFBR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB43638 unconjugated
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应用备注
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ELISA: 1: 5000approx. 1: 10000. Western Blot: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression." in: Frontiers in pharmacology, Vol. 8, pp. 779, (2017) (PubMed).
: "Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway." in: International journal of molecular medicine, Vol. 32, Issue 1, pp. 151-7, (2013) (PubMed).
: "Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa." in: Human reproduction (Oxford, England), Vol. 27, Issue 7, pp. 1985-93, (2012) (PubMed).
: "The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 18700-9, (2012) (PubMed).
: "Nitric oxide enhances melanogenesis of alpaca skin melanocytes in vitro by activating the MITF phosphorylation." in: Molecular and cellular biochemistry, Vol. 352, Issue 1-2, pp. 255-60, (2011) (PubMed).
: "Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4291-301, (2010) (PubMed).
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- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
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别名
- TGFBR1 / ALK-5
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背景
- Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.Synonyms: ALK5, Activin receptor-like kinase 5, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type-1, TGF-beta type I receptor, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I
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分子量
- approx. 55 kDa
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基因ID
- 7046
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NCBI登录号
- NP_001124388
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UniProt
- P36897
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途径
- Growth Factor Binding
抗原
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