GRK1 抗体
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北京 101111
Quick Overview for GRK1 抗体 (ABIN317886)
抗原
See all GRK1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- GRK1 antibody detects endogenous levels of GRK1 protein.(region surrounding Ala17)
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纯化方法
- Affinity chromatography
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anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (AA 1-160) antibody
GRK1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) antibodyGRK1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (AA 520-550), (C-Term) antibodyGRK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0900 unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) antibodyGRK1 适用: 人, 小鼠, 大鼠, Cow, 小鸡 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (N-Term) antibodyGRK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (AA 51-150) antibodyGRK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (Thr8) antibodyGRK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) antibodyGRK1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 1 (GRK1) (AA 6-55), (pSer21) antibodyGRK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- GRK1 (G Protein-Coupled Receptor Kinase 1 (GRK1))
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别名
- Rhodopsin Kinase
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背景
- Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β), two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2), IT-11 (GRK 4), GRK 5, GRK 6, and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.Synonyms: G protein-coupled receptor kinase 1, GRK1, RHOK
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分子量
- approx. 63 kDa
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基因ID
- 6011
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NCBI登录号
- NP_002920
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UniProt
- Q15835
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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