CLCN4 抗体
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Quick Overview for CLCN4 抗体 (ABIN317826)
抗原
See all CLCN4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of CLC-4 protein.(region surrounding Glu254)
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse and Rat.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Chloride Channel 4 (CLCN4) (AA 663-689), (C-Term) antibody
CLCN4 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB0752 unconjugated
anti-Chloride Channel 4 (CLCN4) (Internal Region) antibodyCLCN4 适用: 人, 大鼠, 小鼠 WB, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 4 (CLCN4) antibodyCLCN4 适用: 人 WB, IF, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 4 (CLCN4) (Internal Region) antibodyCLCN4 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 4 (CLCN4) (Internal Region) antibodyCLCN4 适用: 人, 大鼠, 小鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 4 (CLCN4) (AA 221-270) antibodyCLCN4 适用: 人, 大鼠, 小鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 4 (CLCN4) (C-Term) antibodyCLCN4 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 60000approx. 1: 80000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CLCN4 (Chloride Channel 4 (CLCN4))
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别名
- CLCN4
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背景
- The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.Synonyms: CLC4, Chloride channel protein 4, Chloride transporter ClC-4, ClC-4, ClC4, H(+)/Cl(-) exchange transporter 4
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分子量
- approx. 85 kDa
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基因ID
- 1183
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NCBI登录号
- NP_001821
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UniProt
- P51793
抗原
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