CRHR2 抗体
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北京 101111
Quick Overview for CRHR2 抗体 (ABIN317630)
抗原
See all CRHR2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of CRF-RII protein.(region surrounding Tyr113)
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纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 243-272) antibody
CRHR2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB19234 unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 20-108) antibodyCRHR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 10-39) antibodyCRHR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB08932 unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 84-114), (N-Term) antibodyCRHR2 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19233 unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 51-150) antibodyCRHR2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (N-Term) antibodyCRHR2 适用: 人, Cow, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (N-Term) antibodyCRHR2 适用: 人, 大鼠, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 27-58) antibodyCRHR2 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) antibodyCRHR2 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone Receptor 2 (CRHR2) (AA 20-34), (Extracellular), (N-Term) antibodyCRHR2 适用: 大鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))
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别名
- CRHR2
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背景
- Individuals suffering from Alzheimer's disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in postmortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of ''free CRF'' available to bind CRFRs. Two CRF receptors, designated CRF-RI and CFR-RII, exhibit distinct brain localizations.Two forms of CFR-RII, designated CFR-RIIalpha and CFR-RIIbeta, result from alternative mRNA splicing. Urocortin, an additional member of the CRF family, shares 63 % sequence identity with urotensin and 45 % sequence identity with CRF. Urocortin specifically binds to and activates CRF-RI and CRF-RII, but binds to CRF-RII more efficiently than CRF, suggesting that it may be the true, high affinity ligand for the CRF receptor type II.Synonyms: CRF-R 2, CRF2, CRF2R, CRH2R, Corticotropin-releasing factor receptor 2, Corticotropin-releasing hormone receptor 2
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基因ID
- 1395
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NCBI登录号
- NP_001189404
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UniProt
- Q13324
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途径
- Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour
抗原
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