DNMT3B 抗体
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北京 101111
Quick Overview for DNMT3B 抗体 (ABIN317617)
抗原
See all DNMT3B 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Dnmt3b protein.(region surrounding His7)
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纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-150) antibody
DNMT3B 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4D1A2E5 unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-150) antibodyDNMT3B 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7E5E9C1 unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 389-417) antibodyDNMT3B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01906 unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-80) antibodyDNMT3B 适用: 人, 小鸡 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (N-Term) antibodyDNMT3B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-100) antibodyDNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (N-Term) antibodyDNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-80) antibodyDNMT3B 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 389-417) antibodyDNMT3B 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibodyDNMT3B 适用: 人 WB, FACS, ICC, DB 宿主: 小鼠 Monoclonal 2280C3a unconjugated
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应用备注
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ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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别名
- DNMT3B
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背景
- Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.Synonyms: DNA (cytosine-5)-methyltransferase 3B, DNA MTase HsaIIIB, DNA methyltransferase HsaIIIB, M.HsaIIIB
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基因ID
- 1789
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NCBI登录号
- NP_008823
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UniProt
- Q9UBC3
抗原
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