This antibody recognizes CD70, a 29 kDa type II transmembrane protein that belongs to the tumour necrosis factor (TNF) family. CD70 is expressed on a small number of activated T-cells and the majority of activated B-cells. Interaction of CD70 with its receptor, CD27, is thought to play an important role in lymphocyte activation, proliferation, survival and differentiation.
Immunohistochemistry on frozen sections. Flow Cytometry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containssodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled bytrained staff only.
CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.Synonyms: CD27 ligand, CD27L, CD27LG, TNFSF7, Tumor necrosis factor ligand superfamily member 7