GLI1 抗体
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北京 101111
Quick Overview for GLI1 抗体 (ABIN307152)
抗原
See all GLI1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit anti Human Zinc Finger Protein GLI1
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交叉反应
- 人
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产品特性
- Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Synthetic peptide derived from human zinc finger protein GLI1.
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应用备注
- Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- GLI1 (Zinc Finger Protein GLI1 (GLI1))
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别名
- Zinc Finger Protein GLI1
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背景
- Glioma-associated oncogene, Oncogene GLI
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UniProt
- P08151
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途径
- Hedgehog Signaling, Dopaminergic Neurogenesis
抗原
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