ALOX5AP 抗体
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北京 101111
Quick Overview for ALOX5AP 抗体 (ABIN307146)
抗原
See all ALOX5AP 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit anti Human FLAP
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交叉反应
- 人
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产品特性
- Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Synthetic peptide derived from human FLAP protein.
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应用备注
- Antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))
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别名
- FLAP
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背景
- FLAP, Arachidonate 5-lipoxygenase-activating protein, MK 886 binding protein
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UniProt
- P20292
抗原
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