ELOVL4 抗体
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- 抗原 See all ELOVL4 抗体
- ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ELOVL4 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 产品特性
- Elongation of very long chain fatty acids protein 4, ELOV4,Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.
- 纯化方法
- Ammonium Sulfate Precipitation
- 免疫原
- Synthetic peptdide derived from the human ELOV4 protein
- 亚型
- IgG
- Top Product
- Discover our top product ELOVL4 Primary Antibody
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anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (AA 270-314) antibody
ELOVL4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (AA 1-100) antibodyELOVL4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (Internal Region) antibodyELOVL4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (Internal Region) antibodyELOVL4 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (AA 286-314), (C-Term) antibodyELOVL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) (Internal Region) antibodyELOVL4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Antibody can be used for Western blotting (1-5 μg/mL starting dilution). Optimal concentration should be evaluated by serial dilutions.
- 限制
- 仅限研究用
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- 缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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