SMC1A 抗体
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北京 101111
Quick Overview for SMC1A 抗体 (ABIN306835)
抗原
See all SMC1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse anti Human SMC-1
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交叉反应
- 人
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产品特性
- Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus (2) protein in vivo.
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纯化方法
- Protein A/G Chromatography
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亚型
- IgG1, kappa
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anti-Structural Maintenance of Chromosomes 1A (SMC1A) (C-Term) antibody
SMC1A 适用: 人, 小鼠 WB, IHC, ICC, FACS, IF (p), IP 宿主: 兔 Monoclonal BL-205-2G8 unconjugated Recombinant Antibody
anti-Structural Maintenance of Chromosomes 1A (SMC1A) antibodySMC1A 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5B6 unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) antibodyKD Validated SMC1A 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2670 unconjugated Recombinant Antibody
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (pSer957) antibodySMC1A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (pSer966) antibodySMC1A 适用: 人 WB, IP, IHC (fp), IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (AA 1183-1233) antibodySMC1A 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 山羊 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (C-Term) antibodySMC1A 适用: 人 WB, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (AA 366-465) antibodySMC1A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) (N-Term) antibodySMC1A 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1A (SMC1A) antibodySMC1A 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 8C11 unconjugated Recombinant Antibody
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应用备注
- This antibody can be used for Western blotting (1-5 μg/mL) and immunofluorescence (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
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别名
- SMC-1
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UniProt
- Q14683
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途径
- Stem Cell Maintenance
抗原
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