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BUB1B 抗体 (AA 883-1052)

BUB1B 适用: 小鼠 WB, IHC 宿主: 绵羊 Polyclonal unconjugated
产品编号 ABIN306786
发货至: 中国
  • 抗原 See all BUB1B 抗体
    BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))
    抗原表位
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 883-1052
    适用
    • 84
    • 38
    • 14
    • 3
    • 1
    小鼠
    宿主
    • 61
    • 23
    • 3
    绵羊
    克隆类型
    • 59
    • 28
    多克隆
    标记
    • 57
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BUB1B antibody is un-conjugated
    应用范围
    • 70
    • 29
    • 27
    • 26
    • 15
    • 13
    • 13
    • 12
    • 12
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    交叉反应
    小鼠
    产品特性
    Mitotic checkpoint kinase MAD3L,Bub1, a mitotic checkpoint gene first identified in yeast, ensures proper chromosome segregation by delaying anaphase until chromosomes are properly aligned on the mitotic spindle. Mutations in the mitotic spindle assembly checkpoint genes, like yeast Bub1, cause cells to exit mitosis without proper chromosome attachment/alignment, resulting in aneuploidy. Aneuploidy is a form of genetic instability involved in cancer. Recently, a novel homologue of the murine Bub1 gene has been identified and named Bub1b. The yeast mitotic checkpoint pathway is unresolved, but the mammalian pathway remains even less clear. It is important to investigate the role of the Bub1 genes in the mammalian checkpoint as they have been implicated in carcinogenesis, namely colon carcinomas. The aneuploidy and chromosome instability characterizing some tumors is thought to be caused by mutations in Bub1.
    纯化方法
    Ammonium Sulfate Precipitation
    免疫原
    Recombinant protein corresponding to amino acids 883-1052 of the mouse Bub1b protein.
    亚型
    IgG
    Top Product
    Discover our top product BUB1B Primary Antibody
  • 应用备注
    Antibody detects Bub1b in mitotic cells seperated from NIH/3T3 cells by IP/Westen blot (1-10 μg/mL) analysis. Detects a 130 kDa band. Optimal concentration should be evaluated by serial dilutions.
    限制
    仅限研究用
  • 缓冲液
    Provided as solution in phosphate buffered saline with 0.08 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
  • 抗原
    BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))
    别名
    Bub1 beta (BUB1B 产品)
    UniProt
    Q9Z1S0
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