S1PR5 抗体
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北京 101111
Quick Overview for S1PR5 抗体 (ABIN306731)
抗原
See all S1PR5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit anti Human Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)
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交叉反应
- 人
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产品特性
- Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.
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纯化方法
- Ammonium Sulfate Precipitation
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亚型
- IgG
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应用备注
- Detects recombinant EDG8 receptors by Western blot (5-10 μg/mL) at 42 kDa. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))
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别名
- Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)
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背景
- Endothelial Cell Differentiation Gene-8 Receptor C-Terminal
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UniProt
- Q9H228
抗原
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