ARHGEF2 抗体
Our Local Distributor
北京 101111
Quick Overview for ARHGEF2 抗体 (ABIN306728)
抗原
See all ARHGEF2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 小鼠
-
产品特性
- Rho guanine nucleotide exchange factor 2, ARHGEF2,Lfc is a 118 kDa protein discovered in a screen for oncogenes in NIH 3T3 cells. Lfc is a signaling protein related to Lbc and is part of the Dbl family of proteins. Lfc is a guanine-nucleotide exchange factor (GEF) for the Rho family of small GTPases. Lfc has also been shown to be upstream of the serine-threonine kinase JNK. Lfc has also been shown to mediate the activation of the Rac signaling pathway.
-
纯化方法
- Ammonium Sulfate Precipitation
-
免疫原
- Antibody developed using protein corresponding to amino acids 2 to 447 of the Lfc protein fused to GST.
-
亚型
- IgG
-
-
-
-
应用备注
- Detects Lfc in mouse tissues by immunoprecipitation-Western blot at 4 μg/mL. Detects a 118 kDa band in mouse tissue extracts corresponding to wild-type Lfc. Can also be used in immunofluorescence assays. Optimal concentration should be evaluated by serial dilutions.
-
限制
- 仅限研究用
-
-
-
缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
-
-
- ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
-
别名
- LFC
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-