AKAP12
适用: 人
IHC, ELISA, IF
宿主: 兔
Polyclonal
unconjugated
应用备注
Antibody can be used for Western blot (2-5 ug/ml), immunohistochemistry and immunoprecipitation. Positive Control: Rat aortic smooth muscle.
限制
仅限研究用
浓度
1 mg/ml
储存条件
-20 °C
抗原
AKAP12
(A Kinase (PRKA) Anchor Protein 12 (AKAP12))
别名
SSeCKS - myristylated (PKC) substrate
背景
Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actin-based stellate morphology of mesangial cellsSynonyms: SSeCKS, A-kinase anchor protein 12, AKAP12, src-suppressed C kinase substrate.