AKAP12 抗体
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北京 101111
Quick Overview for AKAP12 抗体 (ABIN306674)
抗原
See all AKAP12 抗体适用
宿主
克隆类型
标记
应用范围
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亚型
- IgG
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应用备注
- Antibody can be used for Western blot (2-5 ug/ml), immunohistochemistry and immunoprecipitation. Positive Control: Rat aortic smooth muscle.
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限制
- 仅限研究用
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浓度
- 1 mg/ml
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储存条件
- -20 °C
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- AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))
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别名
- SSeCKS - myristylated (PKC) substrate
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背景
- Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actin-based stellate morphology of mesangial cellsSynonyms: SSeCKS, A-kinase anchor protein 12, AKAP12, src-suppressed C kinase substrate.
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UniProt
- Q62766
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途径
- cAMP Metabolic Process
抗原
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