AKAP12 抗体 (AA 301-350)
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北京 101111
Quick Overview for AKAP12 抗体 (AA 301-350) (ABIN1533824)
抗原
See all AKAP12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 301-350
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原理
- AKAP 250 Antibody
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特异性
- AKAP 250 Polyclonal Antibody detects endogenous levels of AKAP 250 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human AKAP12. AA range:301-350
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亚型
- IgG
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应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))
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别名
- AKAP12
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背景
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Synonyms: AKAP12, AKAP250, A-kinase anchor protein 12, AKAP-12, A-kinase anchor protein 250 kDa, AKAP 250, Gravin, Myasthenia gravis autoantigen
Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Gene Name: AKAP12
Protein Name: A-kinase anchor protein 12
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分子量
- 191 kDa
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基因ID
- 9590
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OMIM
- 604698
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UniProt
- Q02952
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途径
- cAMP Metabolic Process
抗原
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