VAV2 抗体
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北京 101111
Quick Overview for VAV2 抗体 (ABIN306672)
抗原
See all VAV2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Sheep anti Human Vav-2 SHD
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交叉反应
- 小鼠
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产品特性
- The immunogen used for the anti-human Vav-2 SHD region was a his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD. Vav-2 has a molecular weight of 100 kD and shares over a 50 % homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl- homology ((DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- A his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD
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亚型
- IgG
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anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) (AA 552-868) antibody
VAV2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5D3 unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) antibodyVAV2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) antibodyKD Validated VAV2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3270 unconjugated Recombinant Antibody
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) antibodyVAV2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56694 unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) (Internal Region) antibodyVerified VAV2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) (AA 108-157), (pTyr142) antibodyVAV2 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) antibodyVAV2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) (Tyr299) antibodyVAV2 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) (AA 570-700) antibodyVAV2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Vav 2 Guanine Nucleotide Exchange Factor (VAV2) antibodyVAV2 适用: 人 WB, IP 宿主: 绵羊 Polyclonal unconjugated
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应用备注
- Applications: Western Blot 1:5,000. Immunoprecipitation -Empirical
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
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别名
- Vav-2 SHD
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背景
- VAV-2, Guanine nucleotide exchange factor VAV-2, Src homology 2 and 3 (SH2 & SH3) domains
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UniProt
- P52735
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途径
- Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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