ZBTB7A 抗体 (N-Term)
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北京 101111
Quick Overview for ZBTB7A 抗体 (N-Term) (ABIN3044569)
抗原
See all ZBTB7A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-ZBTB7A Antibody
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序列
- DLLERQILAA DDVGDASQPD GAGPTDQRNL LRAKEYLEF
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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预测反应
- different from the related human sequence by eleven amino acids,and from the related rat sequence by one amino acid.
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产品特性
- Anti-ZBTB7A Antibody. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of mouse ZBTB7A, different from the related human sequence by eleven amino acids, and from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (AA 151-250) antibody
ZBTB7A 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (N-Term) antibodyZBTB7A 适用: 人 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) antibodyZBTB7A 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (AA 1-108) antibodyZBTB7A 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2A2 unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (N-Term) antibodyZBTB7A 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) antibodyZBTB7A 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2395 unconjugated Recombinant Antibody
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (C-Term) antibodyZBTB7A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (N-Term) antibodyZBTB7A 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (AA 224-273) antibodyZBTB7A 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 7A (ZBTB7A) (AA 114-163) antibodyZBTB7A 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat Western blot, 0.1-0.5 μg/mL, Mouse
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- ZBTB7A (Zinc Finger and BTB Domain Containing 7A (ZBTB7A))
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别名
- Zbtb7a
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背景
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Background: Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene. ZBTB7A has a critical oncosuppressive role in the prostate. Prostate-specific inactivation of ZBTB7A leads to a marked acceleration of PTEN loss-driven prostate tumorigenesis through bypass of PTEN loss-induced cellular senescence. It has been showed that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA. Inactivation of ZBTB7A in vivo leads to RB downregulation, bypass of PTEN loss-induced cellular senescence, and invasive prostate cancer. Notably, it has been also found that ZBTB7A is genetically lost, as well as downregulated at both the mRNA and protein levels, in a subset of human advanced prostate cancers. Therefore, ZBTB7A is identified as a context-dependent cancer gene that can act as an oncogene in some contexts but that also has oncosuppressive-like activity in PTEN-null tumors.
Gene Full Name: zinc finger and BTB domain containing 7a
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分子量
- 75 kDa
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基因ID
- 16969
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UniProt
- O88939
抗原
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