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TREM1 抗体 (AA 74-90)

TREM1 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044450
发货至: 中国
  • 抗原 See all TREM1 抗体
    TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))
    抗原表位
    • 15
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    • 2
    • 2
    • 1
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    AA 74-90
    适用
    • 67
    • 47
    • 39
    • 15
    • 1
    • 1
    • 1
    小鼠, 大鼠
    宿主
    • 70
    • 16
    • 7
    • 1
    克隆类型
    • 71
    • 21
    • 1
    多克隆
    标记
    • 41
    • 6
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    This TREM1 antibody is un-conjugated
    应用范围
    • 71
    • 48
    • 30
    • 24
    • 12
    • 8
    • 8
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
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    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Anti-TREM1 Antibody Picoband®
    序列
    FTRPSEVHMG KFTLKHD
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-TREM1 Antibody (ABIN3044450). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence in the middle of mouse TREM1.
    亚型
    IgG
    Top Product
    Discover our top product TREM1 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse
    1. Allcock, R. J. N., Barrow, A. D., Forbes, S., Beck, S., Trowsdale, J.The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.Europ. J. Immun. 33: 567-577, 2003. 2. Bouchon, A., Dietrich, J., Colonna, M.Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.J. Immun. 164: 4991-4995, 2000.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Zhou, Xiong, Huang, Tang, Yu, Lan: "Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis." in: Scientific reports, Vol. 5, pp. 17901, (2016) (PubMed).

  • 抗原
    TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))
    别名
    TREM1 (TREM1 产品)
    背景

    Synonyms: Triggering receptor expressed on myeloid cells 1,TREM-1,CD354,Trem1,

    Tissue Specificity: Brain.

    Background: Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF), MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules (e.g., ITGB1) and costimulatory molecules (e.g., CD40). Trem1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.

    Sequence Similarities: Belongs to the SPARC family.

    分子量
    22-26 kDa
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