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TIMP2 抗体 (C-Term)

Name: TIMP2 抗体 (C-Term)
SKU: ABIN3044332
Availability: OutOfStock

TIMP2 适用: 人 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti-TIMP2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (TIMP2 抗体 (C-Term))

IHC

1 image

(15 references)

产品编号 ABIN3044332

发货至: 中国

Datasheet as PDF

抗原 See all TIMP2 抗体

TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
抗原表位
18

16

15

15

15

11

6

5

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 205-220, C-Term
适用
106

100

67

25

24

23

21

12

12

10

10

7

3

3

1

1

1

1
人
宿主
110

38

8

3

1
兔
Compatible Secondaries
克隆类型
110

49
多克隆
标记
75

18

8

5

5

5

5

5

5

4

3

3

3

3

3

2

2

1

1

1

1

1

1
This TIMP2 antibody is un-conjugated
应用范围
127

46

41

40

32

31

29

15

14

14

12

9

4

4

2

2

2

1

1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with IHC-P, ELISA in Human,Mouse,Rat.

序列

RGAAPPKQEF LDIEDP

交叉反应（详细）

Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

产品特性

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with IHC-P, ELISA in Human,Mouse,Rat.
Gene Name: TIMP metallopeptidase inhibitor 2
Protein Name: Metalloproteinase inhibitor 2

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2(205-220aa RGAAPPKQEFLDIEDP), identical to the related mouse and rat sequences.

亚型

IgG

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anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 100-200) antibody
TIMP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) antibody
TIMP2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C3 unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) antibody
TIMP2 适用: 人, 大鼠, 小鼠, 犬, 猴 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1A6 unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) antibody
TIMP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5D7 unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 131-220) antibody
TIMP2 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 51-150) antibody
TIMP2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) antibody
TIMP2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) antibody
TIMP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) antibody
TIMP2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C3 unconjugated

anti-Metalloproteinase Inhibitor 2 (TIMP2) antibody
TIMP2 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated

应用备注

IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Tang, Pei, Yang, Wang, Wang, Gao, Li, Yang, Yang: "The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Zeng, Li, Li, Li, Xiao, Chu, Yang: "Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats." in: Bioengineered, Vol. 7, Issue 5, pp. 314-320, (2017) (PubMed).

et al.: "Erratum: Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway ..." in: International journal of nanomedicine, Vol. 12, pp. 1515, (2017) (PubMed).

Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

Zhou, Zhang, Gao, Zhang, Kong: "Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers." in: Journal of ophthalmology, Vol. 2016, pp. 4952340, (2016) (PubMed).

Ye, Wang, Zhang, Song, Yang, Li, Li, Su, Yang, Ma: "Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120178, (2015) (PubMed).

Wu, Zhang, Qu, Feng, Tian, Zhang, Li, Sun, Liu: "MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 56-63, (2014) (PubMed).

Xu, Ling, Zhu, Fan, Zhang: "The effect of 2,3,4',5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms." in: European journal of pharmacology, Vol. 698, Issue 1-3, pp. 370-8, (2013) (PubMed).

Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).

Hu, Wang, Zhao, Hu, Lu, Qin: "Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats." in: Molecular biology reports, Vol. 40, Issue 2, pp. 1429-41, (2013) (PubMed).

Shan, Zhou, He, Feng, Chen, Zhong: "Expression of both matrix metalloproteinase-2 and its tissue inhibitor-2 in tunica media of radial artery in uremic patients." in: Renal failure, Vol. 35, Issue 1, pp. 37-42, (2013) (PubMed).

Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).

Qiu, Zhou, Wang, Yang, Liu, Xu, Qi, Ding, Guo: "Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats." in: Toxicology, Vol. 285, Issue 1-2, pp. 31-8, (2011) (PubMed).

Fan, Zhao, Fu, Chen, Sun: "Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 9, Issue 4, pp. 414-22, (2011) (PubMed).
抗原

TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

别名

TIMP2 (TIMP2 产品)

别名

CSC-21K antibody, DDC8 antibody, timp2l antibody, zgc:65967 antibody, zgc:85799 antibody, D11Bwg1104e antibody, Timp-2 antibody, TIMP-2 antibody, etID32613.12 antibody, fa96h09 antibody, timp2 antibody, wu:fa96h09 antibody, zgc:136726 antibody, TIMP metallopeptidase inhibitor 2 antibody, TIMP metallopeptidase inhibitor 2b antibody, tissue inhibitor of metalloproteinase 2 antibody, TIMP metallopeptidase inhibitor 2a antibody, TIMP metallopeptidase inhibitor 2 L homeolog antibody, TIMP2 antibody, timp2b antibody, Timp2 antibody, timp2a antibody, timp2.L antibody

背景

TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Synonyms: CSC 21K antibody|CSC-21K antibody|CSC21K antibody|Metalloproteinase inhibitor 2 antibody|Metalloproteinase inhibitor 2 precursor antibody|TIMP 2 antibody|TIMP metallopeptidase inhibitor 2 antibody|TIMP-2 antibody|TIMP2 antibody|TIMP2_HUMAN antibody|Tissue Inhibitor of Metalloproteinase 2 antibody|Tissue inhibitor of metalloproteinases 2 antibody

UniProt

P16035

途径

cAMP Metabolic Process