CYBB 抗体 (Middle Region)
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北京 101111
Quick Overview for CYBB 抗体 (Middle Region) (ABIN3044252)
抗原
See all CYBB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 442-459, Middle Region
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原理
- Anti-NOX2/gp91phox/CYBB Antibody
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序列
- YWLCRDTHAF EWFADLLQ
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-NOX2/gp91phox/CYBB Antibody (ABIN3044252). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human NOX2, identical to the related rat and mouse sequences.
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亚型
- IgG
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anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 501-570) antibody
CYBB 适用: 人, 小鼠, 大鼠, 兔, 小鸡 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) antibodyCYBB 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5135 unconjugated Recombinant Antibody
anti-Cytochrome B-245, beta Polypeptide (CYBB) (C-Term) antibodyCYBB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) antibodyCYBB 适用: 人 WB, IF, IHC (p), ICC 宿主: 小鼠 Monoclonal 54-1 unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 100-200) antibodyCYBB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (Internal Region) antibodyVerified CYBB 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 416-500) antibodyCYBB 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation." in: Scientific reports, Vol. 6, pp. 30146, (2018) (PubMed).
: "Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity." in: Scientific reports, Vol. 6, pp. 23135, (2017) (PubMed).
: "Obligatory role for GPER in cardiovascular aging and disease." in: Science signaling, Vol. 9, Issue 452, pp. ra105, (2017) (PubMed).
: "Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells." in: Carbohydrate polymers, Vol. 125, pp. 135-45, (2015) (PubMed).
: "NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats." in: Neuroscience, Vol. 286, pp. 281-92, (2015) (PubMed).
: "D?galactose?induced mitochondrial DNA oxidative damage in the auditory cortex of rats." in: Molecular medicine reports, Vol. 10, Issue 6, pp. 2861-7, (2014) (PubMed).
: "Oxidative burst of circulating neutrophils following traumatic brain injury in human." in: PLoS ONE, Vol. 8, Issue 7, pp. e68963, (2013) (PubMed).
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: "Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation." in: Scientific reports, Vol. 6, pp. 30146, (2018) (PubMed).
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- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
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别名
- CYBB
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背景
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Synonyms: Cytochrome b-245 heavy chain,1.-.-.-,CGD91-phox,Cytochrome b (558) subunit beta,Cytochrome b558 subunit beta,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,p22 phagocyte B-cytochrome,CYBB,NOX2,
Tissue Specificity: Detected in neutrophils (at protein level). .
Background: NOX2 (NADPH OXIDASE 2), also called CYBB (CYTOCHROME b (-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein.NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 is a heterodimer composed of an alpha chain of relative molecular mass 23 kD and a beta chain of 76 to 82 kD. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling).
Sequence Similarities: Contains 1 FAD-binding FR-type domain.
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分子量
- 65 kDa
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UniProt
- P04839
抗原
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