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MAG 抗体 (N-Term)

Name: MAG 抗体 (N-Term)
SKU: ABIN3044143
Availability: OutOfStock

MAG 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti-MAG antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Rat Brain Tissue Lysate Lane 3: Mouse Brain Tissue Lysate Lane 4: Mouse Brain Tissue Lysate (MAG 抗体 (N-Term))

Observed bind size: 100KD (MAG 抗体 (N-Term))

Anti-MAG antibody, IHC(P) IHC(P): Rat Brain Tissue (MAG 抗体 (N-Term))

IHC

Anti-MAG antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (MAG 抗体 (N-Term))

IHC

4 images

产品编号 ABIN3044143

发货至: 中国

Datasheet as PDF

抗原 See all MAG 抗体

MAG (Myelin Associated Glycoprotein (MAG))
抗原表位
15

8

7

5

2

2

2

2

2

2

1

1

1
AA 114-132, N-Term
适用
58

30

26

3

2

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
50

10
兔
Compatible Secondaries
克隆类型
51

9
多克隆
标记
31

4

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MAG antibody is un-conjugated
应用范围
51

27

13

13

11

11

8

4

3

3

3

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Myelin-associated glycoprotein(MAG) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

序列

KYYFRGDLGG YNQYTFSEH

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Myelin-associated glycoprotein(MAG) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: myelin associated glycoprotein
Protein Name: Myelin-associated glycoprotein

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human MAG(114-132aa KYYFRGDLGGYNQYTFSEH), identical to the related rat and mouse sequences.

亚型

IgG

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anti-Myelin Associated Glycoprotein (MAG) (AA 119-209) antibody
MAG 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3C7 unconjugated

anti-Myelin Associated Glycoprotein (MAG) (C-Term) antibody
MAG 适用: 人, 大鼠 WB, IHC, IF, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
抗原

MAG (Myelin Associated Glycoprotein (MAG))

别名

MAG (MAG 产品)

背景

MAG(Myelin-associated glycoprotein),also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney(HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.

Synonyms: GMA antibody|MAG antibody|MAG_HUMAN antibody|Myelin associated glycoprotein antibody|Myelin-associated glycoprotein antibody|S MAG antibody|Siglec 4a antibody|Siglec-4a antibody|SIGLEC4A antibody

UniProt

P20916

途径

Neurotrophin Signaling Pathway