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CD68 抗体 (C-Term)

Name: CD68 抗体 (C-Term)
SKU: ABIN3044053
Availability: OutOfStock

CD68 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti-CD68 antibody, IHC(P) IHC(P): Human Tonsil Tissue (CD68 抗体 (C-Term))

IHC

Lane 3: Recombinant Human CD68 Protein 2. (CD68 抗体 (C-Term))

2 images

(27 references)

产品编号 ABIN3044053

发货至: 中国

Datasheet as PDF

抗原 See all CD68 抗体

CD68 (CD68 Molecule (CD68))
抗原表位
14

8

6

5

5

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 341-354, C-Term
适用
139

60

36

31

26

17

8

5

1

1

1
人
宿主
88

74

13

1
兔
Compatible Secondaries
克隆类型
108

63

1
多克隆
标记
86

15

12

10

3

3

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD68 antibody is un-conjugated
应用范围
83

76

57

44

36

34

34

20

16

10

8

4

3

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-Macrosialin CD68 Antibody Picoband®

序列

FCIIRRRPSA YQAL

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Macrosialin CD68 Antibody (ABIN3044053). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human CD68.

亚型

IgG

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CD68 适用: 小鼠, 大鼠 FACS, WB, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-CD68 Molecule (CD68) (AA 42-155) antibody
CD68 适用: 人 FACS, WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3F7D3 unconjugated

anti-CD68 Molecule (CD68) (AA 21-120) antibody
CD68 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), ICC, IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人, 小鼠, 大鼠, 猴 FACS, WB, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal C68-684 unconjugated

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人 FACS, WB, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal rLAMP4-824 unconjugated Recombinant Antibody

anti-CD68 Molecule (CD68) (AA 150-301) antibody
CD68 适用: 人 FACS, IHC, ELISA, ISt, StM, Coat 宿主: 小鼠 Monoclonal LAMP4-1830 unconjugated

anti-CD68 Molecule (CD68) (AA 150-221) antibody
CD68 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal C68-2709 unconjugated

anti-CD68 Molecule (CD68) antibody (PE)
CD68 适用: 人 FACS 宿主: 小鼠 Monoclonal Y1-82A PE

anti-CD68 Molecule (CD68) (AA 22-319) antibody
CD68 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-CD68 Molecule (CD68) (AA 1-130) antibody
CD68 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Holness, C. L., Simmons, D. L.Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.Blood 81: 1607-1613, 1993. 2. Jones, E., Quinn, C. M., See, C. G., Montgomery, D. S., Ford, M. J., Kolble, K., Gordon, S., Greaves, D. R.The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13.Genomics 53: 248-250, 1998.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
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Li, Fang, Tian, Wang, Ao, Hou, Tong, Fan, Bai: "Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 4455-4462, (2018) (PubMed).

Chen, Shi, Liu, Ren, He, Chang, Yin: "Activation of corticotropin-releasing factor receptor 1 aggravates dextran sodium sulphate-induced colitis in mice by promoting M1 macrophage polarization." in: Molecular medicine reports, Vol. 17, Issue 1, pp. 234-242, (2018) (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." in: EBioMedicine, Vol. 28, pp. 17-18, (2018) (PubMed).

Zhang, Liang, Zou, Chen, Shi, Wang, Zhang, Li, Zhai: "Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation." in: Bioscience reports, Vol. 38, Issue 3, (2018) (PubMed).

Wang, Liu, Xiong, Xu, Shi, Qiu, Zang, Mao, Zhuang: "Inhibition of EGF Receptor Blocks the Development and Progression of Peritoneal Fibrosis." in: Journal of the American Society of Nephrology : JASN, Vol. 27, Issue 9, pp. 2631-44, (2017) (PubMed).

Liu, Xiao, Liu, Li, Zhou, Xian, Wang, Zhang, Wang, Ho, Zhuang: "SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 11, Issue 3, pp. 592-600, (2017) (PubMed).

Yang, Zhang, Yu, Tang, Gan: "Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation." in: International journal of molecular medicine, Vol. 39, Issue 3, pp. 613-621, (2017) (PubMed).

Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

Wang, Tian, Chen, Tan, Xie, Chen, Fu, Chen, Xu, Wei: "Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice." in: Scientific reports, Vol. 7, Issue 1, pp. 14707, (2017) (PubMed).

Wang, Zhang, Chai, Liu, Li, Wang, Zhu, Cui, Qu, Zhu: "1,25(OH)2D3 downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats." in: Journal of endocrinological investigation, Vol. 38, Issue 10, pp. 1083-91, (2016) (PubMed).

Yan, Fan, Bai, Hou, Li, Tong: "Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway." in: PLoS ONE, Vol. 11, Issue 2, pp. e0148536, (2016) (PubMed).

Zhang, Liu, Zhou, Hu, Qian: "Protective effect of eNOS overexpression against ischemia/reperfusion injury in small-for-size liver transplantation." in: Experimental and therapeutic medicine, Vol. 12, Issue 5, pp. 3181-3188, (2016) (PubMed).

Gu, Wu, Yao, Zeng, Shi, Lv, Luo, Song: "Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway." in: Free radical biology & medicine, Vol. 83, pp. 149-58, (2015) (PubMed).

Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." in: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, (2015) (PubMed).

Pan, Wang, Luo, Wang, Song, Ye, Hou: "Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients." in: Endocrine, Vol. 48, Issue 3, pp. 834-47, (2015) (PubMed).

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抗原

CD68 (CD68 Molecule (CD68))

别名

CD68 (CD68 产品)

背景

Synonyms: Macrosialin,Gp110,CD68,CD68,
Tissue Specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. .
Background: CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.
Sequence Similarities: Belongs to the LAMP family.

分子量

22 kDa

UniProt

P34810