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ROCK2 抗体 (AA 652-923)

Name: ROCK2 抗体 (AA 652-923)
SKU: ABIN3043921
Availability: OutOfStock

ROCK2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 652-923) antibody (ABIN3043921) (ROCK2 抗体 (AA 652-923))

Anti- ROCK2 Picoband antibody,IHC(P) IHC(P): Mouse Cardiac Muscle Tissue (ROCK2 抗体 (AA 652-923))

IHC

Anti- ROCK2 Picoband antibody,IHC(P) IHC(P): Rat Brain Tissue (ROCK2 抗体 (AA 652-923))

IHC

Anti- ROCK2 Picoband antibody,IHC(P) IHC(P): Human Mammary Cancer Tissue (ROCK2 抗体 (AA 652-923))

IHC

4 images

(4 references)

产品编号 ABIN3043921

发货至: 中国

Datasheet as PDF

抗原 See all ROCK2 抗体

ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))
抗原表位
15

15

9

8

6

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 652-923
适用
96

53

52

4

4

3

3

2

2

1

1

1

1
人, 大鼠, 小鼠
宿主
91

7

1
兔
Compatible Secondaries
克隆类型
87

12
多克隆
标记
54

5

5

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This ROCK2 antibody is un-conjugated
应用范围
81

38

27

27

22

18

16

13

11

9

3

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-ROCK2 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-ROCK2 Antibody Picoband® (ABIN3043921). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human ROCK2 recombinant protein (Position: E652-D923). Human ROCK2 shares 94.9% and 95.2% amino acid (aa) sequence identity with mouse and rat ROCK2, respectively.

亚型

IgG

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ROCK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibody
ROCK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibody
KO Validated ROCK2 适用: 人 WB, IP, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1001-1300) antibody
ROCK2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1109-1388) antibody
ROCK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibody
ROCK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibody
ROCK2 适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 10E1 unconjugated Recombinant Antibody

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 511-560) antibody
ROCK2 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬, 猴, 马, 兔, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1389) antibody
ROCK2 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (N-Term) antibody
ROCK2 适用: 人, 大鼠, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Takahashi, N., Tuiki, H., Saya, H., Kaibuchi, K. : Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. Genomics 55: 235-237, 1999. 2. Thumkeo, D., Keel, J., Ishizaki, T., Hirose, M., Nonomura, K., Oshima, H., Oshima, M., Taketo, M. M., Narumiya, S. : Targeted disruption of the mouse Rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Molec. Cell. Biol. 23: 5043-5055, 2003.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Qiao, Zou, Liu, Zhu, Wang, Yang, Jiang, Chen: "ROCK2 mediates the proliferation of pulmonary arterial endothelial cells induced by hypoxia in the development of pulmonary arterial hypertension." in: Experimental and therapeutic medicine, Vol. 11, Issue 6, pp. 2567-2572, (2016) (PubMed).

Yan, Wang, Jiang, Chen, He, Mang, Shao, Xu: "The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia." in: Neural regeneration research, Vol. 10, Issue 9, pp. 1441-9, (2015) (PubMed).

Wang, Wang, Liu, Bai, Zhang, Sun, Wang: "Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats." in: Canadian journal of physiology and pharmacology, Vol. 90, Issue 11, pp. 1506-15, (2012) (PubMed).

Ma, Zhang, Li, Liu, Ma, Li, Falck, Manthati, Reddy, Medhora, Jacobs, Zhu: "8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway." in: Experimental cell research, Vol. 316, Issue 14, pp. 2340-53, (2010) (PubMed).
抗原

ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

别名

ROCK2 (ROCK2 产品)

背景

Synonyms: Rho-associated protein kinase 2,2.7.11.1,Rho kinase 2,Rho-associated, coiled-coil-containing protein kinase 2,Rho-associated, coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2,ROCK2,KIAA0619,
Tissue Specificity: Placenta and lung.
Background: Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

分子量

161 kDa

基因ID

9475

UniProt

O75116

途径

Microtubule Dynamics, WNT signaling, Tube Formation