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IDO1 抗体 (N-Term)

Name: IDO1 抗体 (N-Term)
SKU: ABIN3043857
Availability: OutOfStock

This anti-IDO1 antibody is a 兔多克隆 antibody detecting IDO1 in WB, IHC, IF, FACS 和 ICC. Suitable for 人. This Primary Antibody has been cited in 1 publication.

Anti- IDO1 Picoband antibody, Western blottingAll lanes: Anti IDO1 at 0. (IDO1 抗体 (N-Term))

IHC (p)

2 images

(1 reference)

产品编号 ABIN3043857

发货至: 中国

Quick Overview for IDO1 抗体 (N-Term) (ABIN3043857)

抗原

See all IDO1 抗体

IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This IDO1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Discover our top product IDO1 Primary Antibody

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AA 37-69, N-Term

原理

Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband®

序列

NDWMFIAKHL PDLIESGQLR ERVEKLNMLS IDH

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband® (ABIN3043857). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human IDO1, different from the related mouse sequence by fourteen amino acids, and from the related rat sequence by seventeen amino acids.

亚型

IgG
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibody
Verified IDO1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody
IDO1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E11 unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibody
IDO1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D2 unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibody
IDO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody
IDO1 适用: 小鼠 WB, ELISA, IHC, IF, FACS, IP, FM, MA 宿主: 小鼠 Monoclonal 2E2-6 unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-100) antibody
IDO1 适用: 人, 小鼠 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 304-403) antibody
IDO1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C5 unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibody
IDO1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody
IDO1 适用: 小鼠 WB, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 204-403) antibody
IDO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human1. Burkin, D. J., Kimbro, K. S., Barr, B. L., Jones, C., Taylor, M. W., Gupta, S. L. Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8. Genomics 17: 262-263, 1993. 2. Dai, W., Gupta, S. L. Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. Biochem. Biophys. Res. Commun. 168: 1-8, 1990. 3. Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M.-L., Puccetti, P. Modulation of tryptophan catabolism by regulatory T cells. Nature Immun. 4: 1206-1212, 2003.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Li, Xu, Bai, Yang, Zhao, Zhang, Chen, Wang: "Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase." in: Stem cells international, Vol. 2016, pp. 7495135, (2016) (PubMed).
抗原

IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

别名

IDO1

背景

Synonyms: Indoleamine 2,3-dioxygenase 1,IDO-1,1.13.11.52,Indoleamine-pyrrole 2,3-dioxygenase,IDO1,IDO, INDO,
Background: IDO1 (INDOLEAMINE 2,3-DIOXYGENASE), INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. INDO Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
Sequence Similarities: Belongs to the indoleamine 2,3-dioxygenase family.

分子量

45 kDa

基因ID

3620

UniProt

P14902

途径

Activated T Cell Proliferation