HLA-C 抗体 (C-Term)
Quick Overview for HLA-C 抗体 (C-Term) (ABIN3043843)
抗原
See all HLA-C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 38-62, C-Term
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原理
- Anti-HLA-C Antibody Picoband®
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序列
- EYWDRETQKY KRQAQADRVN LRKLR
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-HLA-C Antibody Picoband® (ABIN3043843). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human HLA-C.
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亚型
- IgG
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anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 25-308) antibody
HLA-C 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 62-306) antibodyHLA-C 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 200-306) antibodyHLA-C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 1-366) antibodyHLA-C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) antibodyHLA-C 适用: 人, Non-Human Primate FACS, IP 宿主: 小鼠 Monoclonal DT-9 unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (PE)HLA-C 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal DT-9 PE
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 25-308) antibody (Biotin)HLA-C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 1-366) antibodyHLA-C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 208-257) antibodyHLA-C 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry , 0.5-1 μg/mL, Human, -
Immunofluorescence, 2 μg/mL, Human, -
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Ríos A, Rodríguez JM, Moya MR, Galindo PJ, Canteras M, Alvarez MR, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg 141 (2): 123-8. 2. Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity 9 (3): 337-44. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
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别名
- HLA-C
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背景
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Synonyms: HLA class I histocompatibility antigen, A-2 alpha chain,MHC class I antigen A*2,HLA-A,HLAA,
Tissue Specificity: Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
Sequence Similarities: Belongs to the MHC class I family.
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分子量
- 41 kDa
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基因ID
- 3107
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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