DAXX 抗体 (AA 56-345)
Quick Overview for DAXX 抗体 (AA 56-345) (ABIN3043822)
抗原
See all DAXX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 56-345
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原理
- Anti-Daxx Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Daxx Antibody Picoband® (ABIN3043822). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Daxx recombinant protein (Position: K56-R345). Human Daxx shares 88.3% and 88.6% amino acid (aa) sequence identity with mouse and rat Daxx, respectively.
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亚型
- IgG
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anti-Death-Domain Associated Protein (DAXX) (AA 561-660) antibody
DAXX 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4C2 unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 558-740) antibodyDAXX 适用: 人 WB, ICC 宿主: 小鼠 Monoclonal DAXX-01 unconjugated
anti-Death-Domain Associated Protein (DAXX) antibodyDAXX 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 7A11 unconjugated
anti-Death-Domain Associated Protein (DAXX) (C-Term) antibodyDAXX 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) antibodyDAXX 适用: 人 WB, IF, EIA 宿主: 小鼠 Monoclonal 7A11 unconjugated
anti-Death-Domain Associated Protein (DAXX) (pSer213) antibodyDAXX 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (pSer495) antibodyDAXX 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 1-740) antibodyDAXX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 580-740) antibodyDAXX 适用: 人 WB, ICC, IP 宿主: 小鼠 Monoclonal DAXX-03 unconjugated
anti-Death-Domain Associated Protein (DAXX) (Center) antibodyDAXX 适用: 人, 猴 WB, IHC, IF, IP, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry , 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., Baltimore, D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860-1863, 1998. 2. Kiriakidou, M., Driscoll, D. A., Lopez-Guisa, J. M., Strauss, J. F., III. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 16: 1289-1298, 1997. 3. Yang, X., Khosravi-Far, R., Chang, H. Y., Baltimore, D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076, 1997. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- DAXX (Death-Domain Associated Protein (DAXX))
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别名
- DAXX
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背景
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Synonyms: Death domain-associated protein 6,Daxx,hDaxx,ETS1-associated protein 1,EAP1,Fas death domain-associated protein,DAXX,BING2, DAP6,
Tissue Specificity: Ubiquitous.
Background: DAXX (death-domain associated protein) also known as DAP6 (Death-associated protein 6) or BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. Human DAXX encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses by Yang et al. (1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The DAXX gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Western blot analysis with DAXX mutants showed that the N terminus of DAXX interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.
Sequence Similarities: Belongs to the DAXX family.
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分子量
- 115 kDa
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基因ID
- 1616
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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