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CTBP1 抗体 (C-Term)

CTBP1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043816
发货至: 中国
  • 抗原 See all CTBP1 抗体
    CTBP1 (C-terminal Binding Protein 1 (CTBP1))
    抗原表位
    • 26
    • 18
    • 8
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    • 2
    • 1
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    • 1
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    AA 409-440, C-Term
    适用
    • 88
    • 54
    • 48
    • 17
    • 5
    • 5
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    • 2
    • 1
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    人, 小鼠, 大鼠
    宿主
    • 101
    • 4
    克隆类型
    • 92
    • 13
    多克隆
    标记
    • 57
    • 7
    • 5
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    • 4
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    • 3
    • 3
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    • 3
    • 3
    • 1
    • 1
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    This CTBP1 antibody is un-conjugated
    应用范围
    • 67
    • 41
    • 26
    • 15
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    • 14
    • 13
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for C-terminal-binding protein 1(CTBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    序列
    HGLPPVAHPP HAPSPGQTVK PEADRDHASD QL
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for C-terminal-binding protein 1(CTBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: C-terminal binding protein 1
    Protein Name: C-terminal-binding protein 1
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human CtBP1 (409-440aa HGLPPVAHPPHAPSPGQTVKPEADRDHASDQL), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
    亚型
    IgG
    Top Product
    Discover our top product CTBP1 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • 抗原
    CTBP1 (C-terminal Binding Protein 1 (CTBP1))
    别名
    CTBP1 (CTBP1 产品)
    别名
    BARS antibody, CtBP1-L antibody, CtBP1-S antibody, CtBP3/BARS antibody, D4S115h antibody, D5H4S115 antibody, D5H4S115E antibody, 50-kDaBFA-inducedADP-ribosylatedsubstrate antibody, BARS-50 antibody, Bars antibody, wu:fi43a11 antibody, CtBP antibody, ctbp1-A antibody, xctbp1 antibody, bars antibody, CTBP1 antibody, C-terminal binding protein 1 antibody, C-terminal binding protein 1 L homeolog antibody, CTBP1 antibody, Ctbp1 antibody, ctbp1 antibody, ctbp1.L antibody
    背景
    CTBP1, C-terminal-binding protein 1, is a protein that in humans is encoded by the CTBP1 gene. The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins. This gene is mapped to 4p16.This phosphoprotein is a transcriptional repressor (corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

    Synonyms: BARS antibody|brefeldin A- ribosylated substrate antibody|C terminal binding protein 1 antibody|C-terminal-binding protein 1 antibody|CTBP antibody|CtBP1 antibody|Ctbp1 antibody| CTBP1_HUMAN antibody|MGC104684 antibody
    基因ID
    1487
    UniProt
    Q13363
    途径
    Retinoic Acid Receptor Signaling Pathway
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