CTBP1 抗体 (C-Term)
Quick Overview for CTBP1 抗体 (C-Term) (ABIN3043816)
抗原
See all CTBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 409-440, C-Term
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原理
- Anti-CtBP1 Antibody Picoband®
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序列
- HGLPPVAHPP HAPSPGQTVK PEADRDHASD QL
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-CtBP1 Antibody Picoband® (ABIN3043816). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CtBP1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
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亚型
- IgG
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anti-C-terminal Binding Protein 1 (CTBP1) (AA 1-429) antibody
CTBP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (AA 20-250) antibodyCTBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (C-Term) antibodyCTBP1 适用: 人, 小鼠, 大鼠, 犬, Pig, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (AA 413-440) antibodyCTBP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) antibodyCTBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (C-Term) antibodyCTBP1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (Internal Region) antibodyCTBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (pSer422) antibodyCTBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (pSer422) antibodyCTBP1 适用: 大鼠, 斑马鱼 ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-C-terminal Binding Protein 1 (CTBP1) (AA 351-440) antibodyCTBP1 适用: 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Immunofluorescence, 2 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Furusawa, T., Moribe, H., Kondoh, H., Higashi, Y.Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor delta-EF1.Molec. Cell. Biol. 19: 8581-8590, 1999. 2. Sewalt, R. G. A. B., Gunster, M. J., van der Vlag, J., Satijn, D. P. E., Otte, A. P.C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins.Molec. Cell. Biol. 19: 777-787, 1999. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CTBP1 (C-terminal Binding Protein 1 (CTBP1))
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别名
- CTBP1
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背景
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Synonyms: C-terminal-binding protein 1,CtBP1,1.1.1.-,CTBP1,CTBP,
Tissue Specificity: Expressed in germinal center B-cells. .
Background: CTBP1, C-terminal-binding protein 1, is a protein that in humans is encoded by the CTBP1 gene. The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins. This gene is mapped to 4p16.This phosphoprotein is a transcriptional repressor (corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.
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分子量
- 48 kDa
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基因ID
- 1487
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UniProt
- Q13363
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途径
- Retinoic Acid Receptor Signaling Pathway
抗原
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