Aspartate beta Hydroxylase 抗体 (C-Term)
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Quick Overview for Aspartate beta Hydroxylase 抗体 (C-Term) (ABIN3043790)
抗原
See all Aspartate beta Hydroxylase (ASPH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 726-758, C-Term
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原理
- Anti-Aspartate beta hydroxylase/ASPH Antibody
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序列
- EVWQDASSFR LIFIVDVWHP ELTPQQRRSL PAI
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Aspartate beta hydroxylase/ASPH Antibody (ABIN3043790). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human ASPH, identical to the related mouse sequence.
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亚型
- IgG
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anti-Aspartate beta-Hydroxylase (ASPH) (AA 345-758) antibody
ASPH 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C13 unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 75-270) antibodyASPH 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (N-Term) antibodyASPH 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 345-758) antibodyASPH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 107-156) antibodyASPH 适用: 人, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 1-210) antibodyASPH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 161-270) antibodyASPH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 1-270) antibodyASPH 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (AA 66-115) antibodyASPH 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aspartate beta-Hydroxylase (ASPH) (Middle Region) antibodyASPH 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry, 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))
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别名
- ASPH
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背景
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Synonyms: Aspartyl/asparaginyl beta-hydroxylase,1.14.11.16 ,Aspartate beta-hydroxylase,ASP beta-hydroxylase,Peptide-aspartate beta-dioxygenase,ASPH,BAH,
Tissue Specificity: Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). .
Background: ASPH is also known as Aspartyl/asparaginyl beta-hydroxylase. This gene is thought to play an important role in calcium homeostasis. And the gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
Sequence Similarities: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
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分子量
- 100 kDa
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基因ID
- 444
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UniProt
- Q12797
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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