ALDH2 抗体 (N-Term)
Quick Overview for ALDH2 抗体 (N-Term) (ABIN3043782)
抗原
See all ALDH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-48, N-Term
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原理
- Anti-ALDH2 Antibody Picoband®
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序列
- SAAATQAVPA PNQQPEVFCN QIFINNEWHD A
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-ALDH2 Antibody Picoband® (ABIN3043782). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human ALDH2, different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 1-380) antibody
ALDH2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibodyALDH2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4G6A3 unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (Center) antibodyALDH2 适用: 人, 小鼠 WB, ELISA, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 408-517) antibodyALDH2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E5 unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibodyALDH2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (N-Term) antibodyALDH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (Internal Region) antibodyVerified ALDH2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibodyALDH2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 138CT22-3-8 unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibodyALDH2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 8C8 unconjugated
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibodyALDH2 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 3F10 unconjugated Recombinant Antibody
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
1. Chen, C.-H., Budas, G. R., Churchill, E. N., Disatnik, M.-H., Hurley, T. D., Mochly-Rosen, D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321: 1493-1495, 2008. 2. Goedde, H. W., Agarwal, D. P., Fritze, G., Meier-Tackmann, D., Singh, S., Beckmann, G., Bhatia, K., Chen, L. Z., Fang, B., Lisker, R., Paik, Y. K., Rothhammer, F., Saha, N., Segal, B., Srivastava, L. M., Czeizel, A. Distribution of ADH-2 and ALDH2 genotypes in different populations. Hum. Genet. 88: 344-346, 1992. 3. Hsu, L. C., Yoshida, A., Mohandas, T. Chromosomal assignment of the genes for human aldehyde dehydrogenase 1 (ALDH1) and aldehyde dehydrogenase 2 (ALDH2). (Abstract) Cytogenet. Cell Genet. 40: 656-657, 1985. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
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别名
- ALDH2
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背景
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Synonyms: Aldehyde dehydrogenase, mitochondrial,1.2.1.3,ALDH class 2,ALDH-E2,ALDHI,ALDH2,ALDM,
Tissue Specificity: Liver, lung, adrenal and adrenocortical adenomas.
Background: ALDH2 (Aldehyde Dehydrogenase 2 Family) is a human gene. The enzyme encoded by this gene belongs to the aldehyde dehydrogenase family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Hsu et al. (1985) assigned the ALDH2 locus to chromosome 12 by means of a cDNA probe and Southern blot analysis of somatic cell hybrids. Using an unbiased proteomic search, Chen et al. (2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models. A high-throughput screen identified a small molecule activator of ALDH2, which they called Alda-1, that, when administered to rats before an ischemic event, reduced infarct size by 60 % , most likely through its inhibitory effect on the formation of cytotoxic aldehydes.
Sequence Similarities: Belongs to the aldehyde dehydrogenase family.
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分子量
- 56 kDa
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基因ID
- 217
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UniProt
- P05091
抗原
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