CBS 抗体 (AA 331-551)
(1 reference)Quick Overview for CBS 抗体 (AA 331-551) (ABIN3043747)
抗原
See all CBS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 331-551
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原理
- Anti-Cystathionine beta-synthase CBS Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Cystathionine beta-synthase CBS Antibody (ABIN3043747). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CBS recombinant protein (Position: A331-K551). Human CBS shares 83% amino acid (aa) sequence identity with both mouse and rat CBS.
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亚型
- IgG
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anti-Cystathionine-beta-Synthase (CBS) (AA 1-100) antibody
CBS 适用: 人 WB, ELISA, IHC (p), IP, RNAi 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 252-551) antibodyCBS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 104-133), (N-Term) antibodyCBS 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22961 unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 1-100) antibodyCBS 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6A9 unconjugated
anti-Cystathionine-beta-Synthase (CBS) (N-Term) antibodyCBS 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 1-413) antibodyCBS 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cystathionine-beta-Synthase (CBS) antibodyCBS 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Cystathionine-beta-Synthase (CBS) antibodyKO Validated CBS 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 301-330) antibodyCBS 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB21183 unconjugated
anti-Cystathionine-beta-Synthase (CBS) (AA 1-100) antibodyCBS 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3D10 unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Munke, M., Kraus, J., Watkins, P., Tanzi, R., Gusella, J., Millington Ward, A., Watson, M., Francke, U.Homocys 2. tinuria gene on human chromosome 21 mapped with cloned cystathionine beta-synthase probe and in situ hybridization of other chromosome 21 probes. (Abstract)Cytogenet. Cell Genet. 40: 706-707, 1985. 3. Kraus, J. P., Oliveriusova, J., Sokolova, J., Kraus, E., Vlcek, C., de Franchis, R., Maclean, K. N., Bao, L., Bukovska, G., Patterson, D., Paces, V., Ansorge, W., Kozich, V.The human cystathionine beta-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms.Genomics 52: 312-324, 1998. 4. Kruger, W. D., Cox, D. R.A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.Proc. Nat. Acad. Sci. 91: 6614-6618, 1994. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats." in: Journal of diabetes research, Vol. 2016, pp. 9726503, (2016) (PubMed).
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: "Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats." in: Journal of diabetes research, Vol. 2016, pp. 9726503, (2016) (PubMed).
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- CBS (Cystathionine-beta-Synthase (CBS))
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别名
- CBS
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背景
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Synonyms: Cystathionine beta-synthase,4.2.1.22,Beta-thionase,Serine sulfhydrase,CBS,
Tissue Specificity: In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Background: Cystathionine-β-synthase, also known as CBS, is an enzyme that in humans is encoded by the CBS gene. It is mapped to 21q22.3 and contains 23 exons, ranging in size from 42 to 299 bp. CBS catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. It uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria.
Sequence Similarities: Belongs to the cysteine synthase/cystathionine beta- synthase family.
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分子量
- 65 kDa
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基因ID
- 875
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UniProt
- P35520
抗原
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