ESR2 抗体 (N-Term)
Quick Overview for ESR2 抗体 (N-Term) (ABIN3043700)
抗原
See all ESR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 27-50, N-Term
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原理
- Anti-Estrogen Receptor beta/ESR2 Antibody Picoband®
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序列
- HGSIYIPSSY VDSHHEYPAM TFYS
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Estrogen Receptor beta/ESR2 Antibody (ABIN3043700). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Estrogen Receptor beta, different from the related rat and mouse sequences by four amino acids.
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亚型
- IgG
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anti-Estrogen Receptor 2 (ESR2) (C-Term) antibody
ESR2 适用: 人, 小鼠, 大鼠, 绵羊, Pig, 马, 猴 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal ERb455 unconjugated
anti-Estrogen Receptor 2 (ESR2) (N-Term) antibodyESR2 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (C-Term) antibodyESR2 适用: 人, 小鼠, 大鼠, 绵羊, Pig, 马, 猴 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal ERb455 unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 201-300) antibodyESR2 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 46-530) antibodyESR2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 211-240) antibodyESR2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB41114 unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 417-428) antibodyVerified ESR2 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 22-121) antibodyESR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F3 unconjugated
anti-Estrogen Receptor 2 (ESR2) (pSer105) antibodyESR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 1-280) antibodyESR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Beleza-Meireles, A., Kockum, I., Lundberg, F., Soderhall, C., Nordenskjold, A. Risk factors for hypospadias in the estrogen receptor 2 gene. J. Clin. Endocr. Metab. 92: 3712-3718, 2007. 2. Fan, X., Warner, M., Gustafsson, J.-A. Estrogen receptor beta expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons. Proc. Nat. Acad. Sci. 103: 19338-19343, 2006. 3. Ogawa, S., Emi, M., Shiraki, M., Hosoi, T., Ouchi, Y., Inoue, S. Association of estrogen receptor beta (ESR2) gene polymorphism with blood pressure. J. Hum. Genet. 45: 327-330, 2000. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ESR2 (Estrogen Receptor 2 (ESR2))
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别名
- ESR2
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背景
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Synonyms: Estrogen receptor beta,ER-beta,Nuclear receptor subfamily 3 group A member 2,ESR2,ESTRB, NR3A2,
Tissue Specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Background: Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.
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分子量
- 65 kDa
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UniProt
- Q92731
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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