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ABI1 抗体 (C-Term)

This anti-ABI1 antibody is a 兔 多克隆 antibody detecting ABI1 in WB, IHC, IF, FACS 和 ICC. Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN3043678
发货至: 中国

Quick Overview for ABI1 抗体 (C-Term) (ABIN3043678)

抗原

See all ABI1 抗体
ABI1 (Abl-Interactor 1 (ABI1))

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

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多克隆

标记

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This ABI1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • 抗原表位

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    AA 483-494, C-Term

    原理

    Anti-SSH3BP1/ABI1 Antibody Picoband®

    序列

    WYEGVCNRVT GL

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-SSH3BP1/ABI1 Antibody (ABIN3043678). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human ABI1, different from the related rat and mouse sequences by one amino acid.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    1. Tani, K., Sato, S., Sukezane, T., Kojima, H., Hirose, H., Hanafusa, H., Shishido, T. : Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian Enabled (Mena) by c-Abl kinase. J. Biol. Chem. 278: 21685-21692, 2003. 2. Taki, T., Shibuya, N., Taniwaki, M., Hanada, R., Morishita, K., Bessho, F., Yanagisawa, M., Hayashi, Y. : ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10,11)(p11.2,q23). Blood 92: 1125-1130, 1998.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.01 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Cui, Yu, Dong, Chen, Zhang, Liu: "Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma." in: Medical oncology (Northwood, London, England), Vol. 27, Issue 3, pp. 632-9, (2010) (PubMed).

  • 抗原

    ABI1 (Abl-Interactor 1 (ABI1))

    别名

    ABI1

    背景

    Synonyms: Abl interactor 1,Abelson interactor 1,Abi-1,Abl-binding protein 4,AblBP4,Eps8 SH3 domain-binding protein,Eps8-binding protein,Nap1-binding protein,Nap1BP,Spectrin SH3 domain-binding protein 1,e3B1,ABI1,SSH3BP1,

    Tissue Specificity: Widely expressed, with highest expression in brain. .

    Background: ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participates in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. ABI1 dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ABI1 plays a role in the leukemogenesis by translocating to MLL.

    Sequence Similarities: Contains 12 fibronectin type-I domains.

    分子量

    60-65 kDa

    途径

    RTK signaling, Response to Water Deprivation, ER-Nucleus Signaling
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