ABI1 抗体 (C-Term)
(1 reference)Quick Overview for ABI1 抗体 (C-Term) (ABIN3043678)
抗原
See all ABI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 483-494, C-Term
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原理
- Anti-SSH3BP1/ABI1 Antibody Picoband®
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序列
- WYEGVCNRVT GL
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SSH3BP1/ABI1 Antibody (ABIN3043678). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human ABI1, different from the related rat and mouse sequences by one amino acid.
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亚型
- IgG
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anti-Abl-Interactor 1 (ABI1) (AA 1-182) antibody
ABI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (AA 180-230) antibodyABI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (AA 151-175), (N-Term) antibodyABI1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) antibodyABI1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (AA 81-108), (N-Term) antibodyABI1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22014 unconjugated
anti-Abl-Interactor 1 (ABI1) antibodyABI1 适用: 人, 大鼠, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (AA 87-117), (N-Term) antibodyABI1 适用: 人 WB, IF, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (AA 81-108) antibodyABI1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (C-Term) antibodyABI1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Abl-Interactor 1 (ABI1) (C-Term) antibodyABI1 适用: 人, 大鼠, 小鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
1. Tani, K., Sato, S., Sukezane, T., Kojima, H., Hirose, H., Hanafusa, H., Shishido, T. : Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian Enabled (Mena) by c-Abl kinase. J. Biol. Chem. 278: 21685-21692, 2003. 2. Taki, T., Shibuya, N., Taniwaki, M., Hanada, R., Morishita, K., Bessho, F., Yanagisawa, M., Hayashi, Y. : ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10,11)(p11.2,q23). Blood 92: 1125-1130, 1998. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.01 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma." in: Medical oncology (Northwood, London, England), Vol. 27, Issue 3, pp. 632-9, (2010) (PubMed).
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: "Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma." in: Medical oncology (Northwood, London, England), Vol. 27, Issue 3, pp. 632-9, (2010) (PubMed).
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- ABI1 (Abl-Interactor 1 (ABI1))
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别名
- ABI1
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背景
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Synonyms: Abl interactor 1,Abelson interactor 1,Abi-1,Abl-binding protein 4,AblBP4,Eps8 SH3 domain-binding protein,Eps8-binding protein,Nap1-binding protein,Nap1BP,Spectrin SH3 domain-binding protein 1,e3B1,ABI1,SSH3BP1,
Tissue Specificity: Widely expressed, with highest expression in brain. .
Background: ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participates in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. ABI1 dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ABI1 plays a role in the leukemogenesis by translocating to MLL.
Sequence Similarities: Contains 12 fibronectin type-I domains.
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分子量
- 60-65 kDa
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途径
- RTK signaling, Response to Water Deprivation, ER-Nucleus Signaling
抗原
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