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TdT 抗体 (AA 316-509)

Name: TdT 抗体 (AA 316-509)
SKU: ABIN3043577
Availability: OutOfStock

DNTT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

Anti-TdT Picoband antibody, All lanes: Anti TDT at 0. (TdT 抗体 (AA 316-509))

2 images

(9 references)

产品编号 ABIN3043577

发货至: 中国

Datasheet as PDF

抗原 See all TdT (DNTT) 抗体

TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
抗原表位
11

8

8

7

6

5

2

2

2

2

1

1

1

1

1

1

1
AA 316-509
适用
78

18

17

4

3

2

2

2

1

1

1
人
宿主
64

15
兔
Compatible Secondaries
克隆类型
59

19

1
多克隆
标记
42

8

5

3

3

2

2

2

2

2

2

2

2

2
This TdT antibody is un-conjugated
应用范围
44

38

13

8

8

7

4

4

3

2

2

1

1

1

1

1

1
Western Blotting (WB)

原理

Anti-TdT/DNTT Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-TdT/DNTT Antibody Picoband® (ABIN3043577). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human TdT recombinant protein (Position: K316-A509). Human TdT shares 81% amino acid (aa) sequence identity with mouse TdT.

亚型

IgG

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DNTT 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B10C3 unconjugated

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DNTT 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H5 unconjugated

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DNTT 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-453R unconjugated Recombinant Antibody

anti-Deoxynucleotidyltransferase, terminal (DNTT) (AA 351-450) antibody
DNTT 适用: 人, 小鼠, 大鼠 ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Deoxynucleotidyltransferase, terminal (DNTT) (AA 1-509) antibody
DNTT 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Deoxynucleotidyltransferase, terminal (DNTT) (Internal Region) antibody
DNTT 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Deoxynucleotidyltransferase, terminal (DNTT) antibody
DNTT 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Deoxynucleotidyltransferase, terminal (DNTT) (N-Term) antibody
DNTT 适用: 人 IHC, IHC (p), HIER 宿主: 小鼠 Monoclonal SEN28 unconjugated

anti-Deoxynucleotidyltransferase, terminal (DNTT) (AA 260-509) antibody
DNTT 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
1. Landau, N. R., St. John, T. P., Weissman, I. L., Wolf, S. C., Silverstone, A. E., Baltimore, D. : Cloning of terminal transferase cDNA by antibody screening. Proc. Nat. Acad. Sci. 81: 5836-5840, 1984. 2. Yang-Feng, T. L., Landau, N. R., Baltimore, D., Francke, U.: The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23-q24) and on mouse chromosome 19. Cytogenet. Cell Genet. 43: 121-126, 1986. 3. Riley, L. K., Morrow, J. K., Danton, M. J., Coleman, M. S.: Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5-prime flanking region. Proc. Nat. Acad. Sci. 85: 2489-2493, 1988.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Yang, Zhang, Ding, Huang, Chen, Wu, Wang, Wang, Chen: "Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer." in: British journal of cancer, Vol. 110, Issue 5, pp. 1288-97, (2014) (PubMed).

Zhang, Pei, Ru, Li, Liu: "Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury." in: Biomedical reports, Vol. 1, Issue 6, pp. 895-900, (2014) (PubMed).

Tochinai, Ando, Suzuki, Suzuki, Nagata, Hata, Uchida, Kobayashi, Kado, Kaneko: "Histopathological studies of microtubule disassembling agent-induced myocardial lesions in rats." in: Experimental and toxicologic pathology : official journal of the Gesellschaft fu?r Toxikologische Pathologie, Vol. 65, Issue 6, pp. 737-43, (2013) (PubMed).

Zeng, Ke, Song, Yao, Hu, Zhang, Li, Yin: "Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance." in: Experimental and molecular pathology, Vol. 95, Issue 1, pp. 23-31, (2013) (PubMed).

Xi, Wang, Ye, Luo, Ning: "Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice." in: PLoS ONE, Vol. 8, Issue 11, pp. e82330, (2013) (PubMed).

Gong, Zheng, Wang, Chen, Pang, Hu, Cao: "Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model." in: World journal of gastroenterology, Vol. 18, Issue 35, pp. 4934-43, (2012) (PubMed).

Luo, Xia: "A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol." in: Anesthesia and analgesia, Vol. 103, Issue 1, pp. 110-6, table of contents, (2006) (PubMed).

Luo, Xia, Ansley, Ouyang, Granville, Li, Xia, Zhou, Liu: "Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation." in: Anesthesia and analgesia, Vol. 100, Issue 6, pp. 1653-9, (2005) (PubMed).

Xu, Liu, Gao, Zhang, Wang, Cao: "Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model." in: Journal of Asian natural products research, Vol. 7, Issue 3, pp. 215-24, (2004) (PubMed).
抗原

TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

别名

DNTT (DNTT 产品)

背景

Synonyms: DNA nucleotidylexotransferase,2.7.7.31 ,Terminal addition enzyme,Terminal deoxynucleotidyltransferase,Terminal transferase ,DNTT,TDT ,
Tissue Specificity: Widely expressed. .
Background: Terminal Deoxynucleotidyl Transferase, also known as TDT and terminal transferase, is a unique DNA polymerase without template ion catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. Its gene is mapped to the region 10q23-q24. And TDT cDNA contains an open reading frame of 1,530 basepairs corresponding to a protein containing 510 amino acids. TDT may be responsible for inserting nucleotides (N regions) at the V (H)-D and D-J (H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells. Additionally, TDT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. Unlike most DNA polymerases it does not require a template. The preferred substrate of this enzyme is a 3'-overhang, but it can also add nucleotides to blunt or recessed 3' ends. Cobalt is a necessary cofactor.
Sequence Similarities: Belongs to the DNA polymerase type-X family.

分子量

58 kDa

基因ID

1791

UniProt

P04053

途径

DNA Damage Repair