PSCA 抗体 (AA 21-95)
(2 references)Quick Overview for PSCA 抗体 (AA 21-95) (ABIN3043554)
抗原
See all PSCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-95
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原理
- Anti-PSCA Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PSCA Antibody Picoband® (ABIN3043554). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PSCA recombinant protein (Position: L21-S95). Human PSCA shares 66% amino acid (aa) sequence identity with mouse PSCA.
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亚型
- IgG
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anti-Prostate Stem Cell Antigen (PSCA) (AA 24-123) antibody
PSCA 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 23-95) antibodyPSCA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C2 unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 23-95) antibodyPSCA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E1 unconjugated
anti-Prostate Stem Cell Antigen (PSCA) antibodyPSCA 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostate Stem Cell Antigen (PSCA) antibodyPSCA 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 12-86) antibodyPSCA 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM87 unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 12-114) antibodyPSCA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 22-123) antibodyPSCA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 22-95) antibodyPSCA 适用: 人 WB 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Prostate Stem Cell Antigen (PSCA) (AA 23-95) antibodyPSCA 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1. Hillerdal V, et al. Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice. BMC Cancer, 2014 Jan 18. 2. Taeb J, et al. Expression of prostate stem cell antigen (PSCA) in prostate cancer: a tissue microarray study of Iranian patients. Pathol Res Pract, 2014 Jan. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population." in: Scientific reports, Vol. 6, pp. 23465, (2017) (PubMed).
: "Small interference RNA-mediated silencing of prostate stem cell antigen attenuates growth, reduces migration and invasion of human prostate cancer PC-3M cells." in: Urologic oncology, Vol. 31, Issue 3, pp. 343-51, (2013) (PubMed).
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: "PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population." in: Scientific reports, Vol. 6, pp. 23465, (2017) (PubMed).
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- PSCA (Prostate Stem Cell Antigen (PSCA))
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别名
- PSCA
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背景
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Synonyms: Prostate stem cell antigen,PSCA,UNQ206/PRO232,
Tissue Specificity: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). .
Background: PSCA is also known as PRO232. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals, this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
Sequence Similarities: Contains 1 UPAR/Ly6 domain.
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分子量
- 25 kDa
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基因ID
- 8000
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UniProt
- O43653
抗原
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