ARNT 抗体 (AA 416-789)
(30 references)Quick Overview for ARNT 抗体 (AA 416-789) (ABIN3043528)
抗原
See all ARNT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 416-789
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原理
- Anti-HIF1 beta/ARNT Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-HIF1 beta/ARNT Antibody Picoband® (ABIN3043528). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HIF1 beta recombinant protein (Position: V416-E789). Human HIF1 beta shares 86% and 83% amino acid (aa) sequences identity with mouse and rat HIF1 beta, respectively.
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亚型
- IgG
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anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 1-110) antibody
ARNT 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3D10 unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 1-789) antibodyARNT 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 2F11 unconjugated Recombinant Antibody
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (C-Term) antibodyARNT 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, 豚鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 小鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 小鼠 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 小鼠 WB, IHC 宿主: 小鼠 Monoclonal 4C5 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Reyes, H., Reisz-Porszasz, S., Hankinson, O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256: 1193-1195, 1992. 2. Wright, C. W., Duckett, C. S. The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappa-B-dependent transcription. Science 323: 251-255, 2009. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway." in: Integrative cancer therapies, Vol. 16, Issue 4, pp. 505-515, (2018) (PubMed).
: "Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 3932-3941, (2018) (PubMed).
: "TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention." in: Molecular medicine reports, Vol. 17, Issue 2, pp. 2229-2238, (2018) (PubMed).
: "CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis." in: Oncotarget, Vol. 8, Issue 14, pp. 22406-22413, (2017) (PubMed).
: "Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways." in: Journal of experimental & clinical cancer research : CR, Vol. 35, Issue 1, pp. 119, (2017) (PubMed).
: "Suppression of the expression of hypoxia-inducible factor-1α by RNA interference alleviates hypoxia-induced pulmonary hypertension in adult rats." in: International journal of molecular medicine, Vol. 38, Issue 6, pp. 1786-1794, (2017) (PubMed).
: "Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." in: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).
: "Effect of Hyperbaric Oxygen on the Growth of Intracranial Glioma in Rats." in: Chinese medical journal, Vol. 128, Issue 23, pp. 3197-203, (2016) (PubMed).
: "Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone." in: Oncology reports, Vol. 35, Issue 3, pp. 1297-308, (2016) (PubMed).
: "Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury." in: Molecular medicine reports, Vol. 13, Issue 3, pp. 1953-60, (2016) (PubMed).
: "Upregulation of metastasis-associated gene 2 promotes cell proliferation and invasion in nasopharyngeal carcinoma." in: OncoTargets and therapy, Vol. 9, pp. 1647-56, (2016) (PubMed).
: "Role of hypoxia-inducible factor-1α in pathogenesis and disease evaluation of ulcerative colitis." in: Experimental and therapeutic medicine, Vol. 11, Issue 4, pp. 1330-1334, (2016) (PubMed).
: "Effect of rapamycin on endometriosis in mice." in: Experimental and therapeutic medicine, Vol. 12, Issue 1, pp. 101-106, (2016) (PubMed).
: "Neuroprotective mechanism of HIF-1α overexpression in the early stage of acute cerebral infarction in rats." in: Experimental and therapeutic medicine, Vol. 12, Issue 1, pp. 391-395, (2016) (PubMed).
: "Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1α signaling pathway." in: FEBS open bio, Vol. 6, Issue 7, pp. 720-8, (2016) (PubMed).
: "Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma." in: World journal of gastroenterology, Vol. 21, Issue 7, pp. 2191-8, (2015) (PubMed).
: "Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging." in: Neural regeneration research, Vol. 7, Issue 10, pp. 778-82, (2015) (PubMed).
: "Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats." in: Neural regeneration research, Vol. 7, Issue 6, pp. 421-5, (2015) (PubMed).
: "Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 29, Issue 4, pp. 820-9, (2014) (PubMed).
: "Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 22, Issue 8, pp. 1197-205, (2014) (PubMed).
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: "Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway." in: Integrative cancer therapies, Vol. 16, Issue 4, pp. 505-515, (2018) (PubMed).
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- ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))
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别名
- ARNT
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背景
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Synonyms: Aryl hydrocarbon receptor nuclear translocator,ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor, nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta,ARNT,BHLHE2,
Tissue Specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. .
Background: ARNT is also known as HIF1-beta or HIF1B. This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. It is mapped to 1q21.3. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. ARNT is a structural component of the XRE-binding form of the Ah receptor. It also functions in concert with RelB in a CD30-induced negative feedback mechanism.
Sequence Similarities: Contains 1 bHLH (basic helix-loop-helix) domain.
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分子量
- 87 kDa
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基因ID
- 405
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UniProt
- P27540
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
抗原
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