BAG2 抗体 (AA 1-211)
Quick Overview for BAG2 抗体 (AA 1-211) (ABIN3043508)
抗原
See all BAG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-211
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原理
- Anti-BAG2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-BAG2 Antibody Picoband® (ABIN3043508). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.
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亚型
- IgG
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anti-BCL2-Associated Athanogene 2 (BAG2) (C-Term) antibody
BAG2 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) antibodyBAG2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (AA 1-211) antibodyBAG2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (C-Term) antibodyVerified BAG2 适用: 人, Pig WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (AA 102-211) antibodyBAG2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E12 unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (C-Term) antibodyBAG2 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, Pig, Cow, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) antibodyKO Validated BAG2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (C-Term) antibodyBAG2 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (AA 148-176), (C-Term) antibodyBAG2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34133 unconjugated
anti-BCL2-Associated Athanogene 2 (BAG2) (AA 151-211) antibodyBAG2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 Molecular chaperone regulators". J Biol Chem 274 (2): 781-6. 2. "Entrez Gene: BAG2 BCL2-associated athanogene 2". -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- BAG2 (BCL2-Associated Athanogene 2 (BAG2))
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别名
- BAG2
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背景
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Synonyms: BAG family molecular chaperone regulator 2,BAG-2,Bcl-2-associated athanogene 2,BAG2,
Tissue Specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). .
Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
Sequence Similarities: Contains 1 P-type (trefoil) domain.
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分子量
- 24 kDa
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基因ID
- 9532
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UniProt
- O95816
抗原
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