TSC1 抗体 (AA 686-884)
Quick Overview for TSC1 抗体 (AA 686-884) (ABIN3043497)
抗原
See all TSC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 686-884
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原理
- Anti-Hamartin/TSC1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Hamartin/TSC1 Antibody Picoband® (ABIN3043497). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Hamartin recombinant protein (Position: D686-Y884). Human Hamartin shares 96% and 95% amino acid (aa) sequences identity with mouse and rat Hamartin, respectively.
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亚型
- IgG
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anti-Tuberous Sclerosis 1 (TSC1) (AA 836-1164) antibody
TSC1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 550-650) antibodyTSC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (C-Term) antibodyTSC1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 836-1164) antibodyTSC1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5A8 unconjugated
anti-Tuberous Sclerosis 1 (TSC1) antibodyTSC1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 401-430) antibodyTSC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibodyTSC1 适用: 人, 小鼠, 绵羊 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 101-344) antibodyTSC1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 401-430) antibodyTSC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11648 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Benvenuto, G., Li, S., Brown, S. J., Braverman, R., Vass, W. C., Cheadle, J. P., Halley, D. J. J., Sampson, J. R., Wienecke, R., DeClue, J. E. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19: 6306-6316, 2000. 2. Choi, Y.-J., Di Nardo, A., Kramvis, I., Meikle, L., Kwiatkowski, D. J., Sahin, M., He, X. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 22: 2485-2495, 2008. 3. Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E., Hariharan, I. K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355, 2001. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TSC1 (Tuberous Sclerosis 1 (TSC1))
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别名
- TSC1
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背景
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Synonyms: Hamartin,Tuberous sclerosis 1 protein,TSC1,KIAA0243, TSC,
Tissue Specificity: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Background: Hamartin also known as tuberous sclerosis 1 is a protein that in humans is encoded by the TSC1 gene. It is mapped to 9q34.13. This peripheral membrane protein was implicated as a tumor suppressor. It forms a complex with TSC2 that regulates mTORC1 signaling and may be also involved in vesicular transport and docking. Hamartin and TSC2 have critical roles in neuronal polarity, and that a common pathway regulates polarization and growth in neurons and cell size in other tissues. Hamartin is a growth inhibitory protein whose biologic effect is probably dependent on its interaction with tuberin. It also can affect cell proliferation via deregulation of G1 phase. Loss or perturbation of Hamartin function leads to loss of adhesion to the cellular matrix and initiates the development of TSC hamartomas.
Sequence Similarities: Belongs to the AP-2 family.
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分子量
- 130 kDa
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基因ID
- 7248
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UniProt
- Q92574
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途径
- RTK signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
抗原
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