CDK2 抗体 (AA 81-298)
(12 references)Quick Overview for CDK2 抗体 (AA 81-298) (ABIN3043472)
抗原
See all CDK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 81-298
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原理
- Anti-Cdk2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Cdk2 Antibody Picoband® (ABIN3043472). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Cdk2 recombinant protein (Position: E81-L298). Human Cdk2 shares 98.6% amino acid (aa) sequence identity with rat Cdk2.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 211-298) antibodyCDK2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2E8 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyCDK2 适用: 人, 猴 WB, FACS, IF 宿主: 小鼠 Monoclonal 4B4 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 197-295) antibodyCDK2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, IF 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibodyCDK2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyCDK2 适用: 人, 猴 WB, FACS, IF 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 94-198) antibodyCDK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 93-211) antibodyCDK2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (pThr160) antibodyCDK2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibodyCDK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994. 2. Tsai, L.-H., Harlow, E., Meyerson, M.Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated P33 kinase.Nature 353: 174-177, 1991. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Circulating exosomal microRNAs reveal the mechanism of Fructus Meliae Toosendan-induced liver injury in mice." in: Scientific reports, Vol. 8, Issue 1, pp. 2832, (2018) (PubMed).
: "Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens." in: Oxidative medicine and cellular longevity, Vol. 2018, pp. 9390810, (2018) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "Effects of tripterygium glycosides on restenosis following endovascular treatment." in: Molecular medicine reports, Vol. 13, Issue 6, pp. 4959-68, (2017) (PubMed).
: "Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro." in: Acta pharmacologica Sinica, Vol. 37, Issue 7, pp. 950-62, (2017) (PubMed).
: "Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment." in: Acta pharmacologica Sinica, Vol. 38, Issue 3, pp. 392-401, (2017) (PubMed).
: "Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells." in: Anti-cancer drugs, Vol. 26, Issue 6, pp. 599-611, (2015) (PubMed).
: "Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo." in: Current cancer drug targets, Vol. 14, Issue 9, pp. 860-71, (2015) (PubMed).
: "Enterovirus 71 mediates cell cycle arrest in S phase through non-structural protein 3D." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 3, pp. 425-36, (2015) (PubMed).
: "Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ..." in: European journal of medicinal chemistry, Vol. 86, pp. 165-74, (2014) (PubMed).
: "The effects of urokinase-type plasminogen activator (uPA) on cell proliferation and phenotypic transformation of rat mesangial cells induced by high glucose." in: Diabetes research and clinical practice, Vol. 103, Issue 3, pp. 489-95, (2014) (PubMed).
: "XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line." in: Chemico-biological interactions, Vol. 183, Issue 1, pp. 133-41, (2009) (PubMed).
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: "Circulating exosomal microRNAs reveal the mechanism of Fructus Meliae Toosendan-induced liver injury in mice." in: Scientific reports, Vol. 8, Issue 1, pp. 2832, (2018) (PubMed).
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- CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
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别名
- CDK2
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背景
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Synonyms: Cyclin-dependent kinase 2,2.7.11.22,Cell division protein kinase 2,p33 protein kinase,CDK2,CDKN2,
Tissue Specificity: Isoform 2 is found in breast cancer tissues.
Background: CDK2, Cyclin-Dependent Kinase2, is also known as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2)/cyclin A. The gene for p33 shares 65 % sequence identity with p34 (cdc2). P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
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分子量
- 33 kDa
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基因ID
- 1017
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UniProt
- P24941
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途径
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
抗原
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