MMP12 抗体 (C-Term)
Quick Overview for MMP12 抗体 (C-Term) (ABIN3043407)
抗原
See all MMP12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 432-466, C-Term
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原理
- Anti-Macrophage metalloelastase MMP12 Antibody Picoband®
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序列
- KIDAVLYFKR HYYIFQGAYQ LEYDPLFRRV TKTLK
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交叉反应 (详细)
- No cross-reactivity with other proteins
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产品特性
- Anti-Macrophage metalloelastase MMP12 Antibody (ABIN3043407). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of mouse MMP12, different from the related human sequence by thirteen amino acids, and from the related rat sequence by three amino acids.
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, -
ELISA, 0.1-0.5 μg/mL, -
1. Houghton, A. M., Hartzell, W. O., Robbins, C. S., Gomis-Ruth, F. X., Shapiro, S. D.Macrophage elastase kills bacteria within murine macrophages. Nature 460: 637-641, 2009. 2. Joos, L., He, J.-Q., Shepherdson, M. B., Connett, J. E., Anthonisen, N. R., Pare, P. D., Sandford, A. J. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Molec. Genet. 11: 569-576, 2002. Note: Erratum: Hum. Molec. Genet. 12: 803-804, 2003. 3. Wu, L., Tanimoto, A., Murata, Y., Sasaguri, T., Fan, J., Sasaguri, Y., Watanabe, T. Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.Genes Cells 8: 225-234, 2003. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
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别名
- Mmp12
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背景
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Synonyms: Macrophage metalloelastase,MME,3.4.24.65,Matrix metalloproteinase-12,MMP-12,Mmp12,Mme, Mmel,
Background: Matrix metalloproteinase-12 (MMP12), also known as MME or ME, is an enzyme that in humans is encoded by the MMP12 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.2. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. This gene may involved in tissue injury and remodeling.
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分子量
- 55 kDa
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基因ID
- 17381
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UniProt
- P34960
抗原
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