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MMP12 抗体 (C-Term)

Name: MMP12 抗体 (C-Term)
SKU: ABIN390136
Availability: OutOfStock

MMP12 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB2026 unconjugated

Anti-P12 Antibody at 1:2000 dilution + human heart lysate Lysates/proteins at 20 μg per lane. (MMP12 抗体 (C-Term))

IHC (p)

Confocal iunofluorescent analysis of P12 Antibody (C-term) (ABIN390136 and ABIN2840640) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). (MMP12 抗体 (C-Term))

Western blot analysis of anti-hP12- Pab (ABIN390136 and ABIN2840640) pre-incubated without(lane 1) and with(lane 2) blocking peptide in 293 cell line lysate. (MMP12 抗体 (C-Term))

Western blot analysis of anti-hP12- Pab (ABIN390136 and ABIN2840640) pre-incubated without(lane 1) and with(lane 2) blocking peptide in mouse kidney tissue lysates. (MMP12 抗体 (C-Term))

Anti-P12 Antibody at 1:1000 dilution + human lung lysate Lysates/proteins at 20 μg per lane. (MMP12 抗体 (C-Term))

6 images

(3 references)

产品编号 ABIN390136

发货至: 中国

Datasheet as PDF

抗原 See all MMP12 抗体

MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
抗原表位
10

7

5

3

3

3

3

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 391-420, C-Term
适用
71

35

34

4

1
人, 小鼠
宿主
89

3

2

1
兔
Compatible Secondaries
克隆类型
80

15
多克隆
标记
40

17

13

4

2

2

2

2

2

2

2

2

1

1

1

1

1
This MMP12 antibody is un-conjugated
应用范围
84

36

34

12

11

11

6

5

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.

克隆位点

RB2026

亚型

Ig Fraction

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anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 100-286) antibody
MMP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 20-99) antibody
MMP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 290-469) antibody
MMP12 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 294-473) antibody
MMP12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 372-463) antibody
MMP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 1-470) antibody
MMP12 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 109-470) antibody
MMP12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (C-Term) antibody
MMP12 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) antibody
MMP12 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (AA 201-300) antibody
MMP12 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:2000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Du, Wang, Tan, Li, Huang, Huang, Yang, Zhang, Wang, Huang, Huang: "Nkx2-5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E-Deficient Mice." in: Journal of the American Heart Association, Vol. 5, Issue 12, (2017) (PubMed).

LaPan, Brady, Grierson, Fleming, Miller, Sypek, Fu: "Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum." in: BMC pulmonary medicine, Vol. 10, pp. 40, (2010) (PubMed).

Ma, Flanc, Tesch, Bennett, Friedman, Nikolic-Paterson: "Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 89, Issue 4, pp. 470-84, (2009) (PubMed).
抗原

MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

别名

MMP12 (MMP12 产品)

别名

MMP12 antibody, AV378681 antibody, Mmel antibody, Mme antibody, HME antibody, ME antibody, MME antibody, MMP-12 antibody, matrix metallopeptidase 12 antibody, MMP12 antibody, Mmp12 antibody

背景

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.

分子量

54002

基因ID

4321

NCBI登录号

NP_002417

UniProt

P39900