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SMAD4 抗体 (C-Term)

Name: SMAD4 抗体 (C-Term)
SKU: ABIN3043341
Availability: OutOfStock

This anti-SMAD4 antibody is a 兔多克隆 antibody detecting SMAD4 in WB. Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 5+ publications.

Anti- SMAD4 Picoband antibody, Western blotting All lanes: Anti SMAD4 at 0. (SMAD4 抗体 (C-Term))

1 image

(5 references)

产品编号 ABIN3043341

发货至: 中国

Datasheet as PDF

Quick Overview for SMAD4 抗体 (C-Term) (ABIN3043341)

抗原

See all SMAD4 抗体

SMAD4 (SMAD Family Member 4 (SMAD4))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This SMAD4 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product SMAD4 Primary Antibody

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AA 526-552, C-Term

原理

Anti-Smad4 Antibody Picoband®

序列

EIHLHRALQL LDEVLHTMPI ADPQPLD

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Smad4 Antibody Picoband® (ABIN3043341). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Smad4, identical to the related mouse and rat sequences.

亚型

IgG
anti-SMAD Family Member 4 (SMAD4) (N-Term) antibody
SMAD4 适用: 人 WB, IP, CUT&RUN 宿主: 兔 Polyclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 1-552) antibody
SMAD4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated

anti-SMAD Family Member 4 (SMAD4) antibody
KO Validated SMAD4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) antibody
SMAD4 适用: 人, 小鼠 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4G1C6 unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 400-428) antibody
SMAD4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 27-195) antibody
SMAD4 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 255-284) antibody
SMAD4 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB14714 unconjugated

anti-SMAD Family Member 4 (SMAD4) (pThr277) antibody
SMAD4 适用: 人 ELISA, IHC, IF, DB 宿主: 兔 Polyclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) antibody
SMAD4 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 3A1 unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 9-231) antibody
SMAD4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Hein, L., Altman, J. D., Kobilka, B. K. :Two functionally distinct alpha-2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181-184, 1999. 2. Hoehe, M. R., Berrettini, W. H., Lentes, K.-U.:Dra I identifies a two allele DNA polymorphism in the human alpha-2-adrenergic receptor gene (ADRAR), using a 5.5 kb probe (p ADRAR). Nucleic Acids Res. 16: 9070 only, 1988. 3. Yang-Feng, T. L., Kobilka, B. K., Caron, M. G., Lefkowitz, R. J., Francke, U.:Chromosomal assignment of genes for an alpha-adrenergic receptor (ADRAR) and for another member of this receptor family coupled to guanine nucleotide regulatory proteins (RG21). (Abstract) Cytogenet. Cell Genet. 46: 722-723, 1987.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Xu, Xu, Saud, Lu, Liu, Fang, Zhang, Hu, Li: "Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 2601830, (2016) (PubMed).

Cheng, Xiao, Ainiwaer, Wang, Wu, Mao, Yang, Bao: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).

Tang, Li, Yu, Gao, Liu, Chen, Xing, Liu, Yao: "Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway." in: The Journal of nutritional biochemistry, Vol. 25, Issue 6, pp. 675-82, (2014) (PubMed).

Chen, Kong, Wan, Xiao, Li, Wang, Lin, Wang: "Effects of huogu I formula (I) on correlated factors of bone regeneration in chickens with steroid-induced necrosis of femoral head." in: Chinese journal of integrative medicine, Vol. 18, Issue 5, pp. 378-84, (2012) (PubMed).

Dong, Jia, Zhang, Li, Geng, Zhou, Li, Liu, Niu: "Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation." in: World journal of gastroenterology, Vol. 15, Issue 38, pp. 4753-62, (2010) (PubMed).
抗原

SMAD4 (SMAD Family Member 4 (SMAD4))

别名

SMAD4

背景

Synonyms: Mothers against decapentaplegic homolog 4,MAD homolog 4,Mothers against DPP homolog 4,Deletion target in pancreatic carcinoma 4,SMAD family member 4,SMAD 4,Smad4,hSMAD4,SMAD4,DPC4, MADH4,
Background: SMAD4 (Mothers Against Decapentaplegic Drosophila Homolog of 4), also known as MADH4 or DPC4, is a protein that in humans is encoded by the SMAD4 gene. It belongs to the Darfwin family of proteins that modulate members of the TGFβ protein superfamily. Hahn et al. (1996) identified the SMAD4 gene on chromosome 18q21.1. Howe et al. (1998) identified the SMAD4 gene within a region on 18q21.1 defined by linkage analysis in kindred with juvenile polyposis syndrome. To test ly the hypothesis that the SMAD4 gene is a tumor suppressor that is critical for transmitting signals from transforming growth factor-beta and related ligands. SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes.
Sequence Similarities: Belongs to the dwarfin/SMAD family.

分子量

60 kDa

基因ID

4089

UniProt

Q13485

途径

Cell Division Cycle, Chromatin Binding, Autophagy