KNG1 抗体 (AA 19-210)
Quick Overview for KNG1 抗体 (AA 19-210) (ABIN3043284)
抗原
See all KNG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-210
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原理
- Anti-Kininogen 1/KNG1 Antibody Picoband®
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交叉反应 (详细)
- No cross-reactivity with other proteins
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产品特性
- Anti-Kininogen 1/KNG1 Antibody Picoband® (ABIN3043284). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Kininogen 1 recombinant protein (Position: Q19-N210). Human Kininogen 1 shares 63% and 66% amino acid (aa) sequence identity with mouse and rat Kininogen 1, respectively.
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: kininogen 1" 2. Fong, D., Smith, D. I., Hsieh, W.-T. The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction. Hum. Genet. 87: 189-192, 1991. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- KNG1 (Kininogen 1 (KNG1))
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别名
- KNG1
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背景
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Synonyms: Kininogen-1,Alpha-2-thiol proteinase inhibitor,Fitzgerald factor,High molecular weight kininogen,HMWK,Williams-Fitzgerald-Flaujeac factor,Kininogen-1 heavy chain,T-kinin,Ile-Ser-Bradykinin,Bradykinin,Kallidin I,Lysyl-bradykinin,Kallidin II,Kininogen-1 light chain,Low molecular weight growth-promoting factor,KNG1,BDK, KNG,
Tissue Specificity: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. .
Background: Kininogen-1 (KNG1), also known as BDK or bradykinin is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins - high - molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, KNG1, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.
Sequence Similarities: Contains 3 cystatin kininogen-type domains.
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分子量
- 72 kDa
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基因ID
- 3827
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UniProt
- P01042
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途径
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
抗原
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