NAE1 抗体 (AA 181-534)
Quick Overview for NAE1 抗体 (AA 181-534) (ABIN3043281)
抗原
See all NAE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 181-534
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原理
- Anti-APPBP1/NAE1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-APPBP1/NAE1 Antibody Picoband® (ABIN3043281). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human APPBP1 recombinant protein (Position: E181-L534). Human APPBP1 shares 98% amino acid (aa) sequence identity with mouse APPBP1.
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亚型
- IgG
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anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 229-534) antibody
NAE1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 1-534) antibodyNAE1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E8-H3 unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 1-220), (Regulatory Subunit) antibodyNAE1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 1-534) antibodyNAE1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 1-534) antibodyNAE1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 430-459), (C-Term) antibodyNAE1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB8977 unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (C-Term) antibodyNAE1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) antibodyNAE1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) antibodyNAE1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 308-357) antibodyNAE1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Hong BH, et al. Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. Neuroreport, 2012 Jan 25. 2. Joo Y, et al. Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. PLoS One, 2010 Dec 2. 3. Zhong HJ, et al. A metal-based inhibitor of NEDD8-activating enzyme. PLoS One, 2012. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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别名
- NAE1
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背景
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Synonyms: NEDD8-activating enzyme E1 regulatory subunit,Amyloid beta precursor protein-binding protein 1, 59 kDa,APP-BP1,Amyloid protein-binding protein 1,Proto-oncogene protein 1,NAE1,APPBP1,HPP1,
Tissue Specificity: Ubiquitous in fetal tissues. Expressed throughout the adult brain. .
Background: NAE1 is also known as APPBP1. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
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分子量
- 42 kDa
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基因ID
- 8883
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UniProt
- Q13564
抗原
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