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KEAP1 抗体 (AA 25-205)

Name: KEAP1 抗体 (AA 25-205)
SKU: ABIN3043275
Availability: OutOfStock

Cited in 2+ publications. This 兔多克隆 anti-KEAP1 antibody specifically detects KEAP1 in WB. The antibody is reactive with 人 samples.

Western Blotting (WB) image for anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 25-205) antibody (ABIN3043275) (KEAP1 抗体 (AA 25-205))

1 image

(2 references)

产品编号 ABIN3043275

发货至: 中国

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Quick Overview for KEAP1 抗体 (AA 25-205) (ABIN3043275)

抗原

See all KEAP1 抗体

KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This KEAP1 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product KEAP1 Primary Antibody

抗原表位
15

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3

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2

1

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1

1

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1

1

1

1
AA 25-205

原理

Anti-Keap1 Antibody

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Keap1 Antibody (ABIN3043275). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Keap1 recombinant protein (Position: E25-E205). Human Keap1 shares 96.7% and 97.2% amino acid (aa) sequence identity with mouse and rat Keap1, respectively.

亚型

IgG
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibody
KEAP1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1B4 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7G4B10 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人, 小鼠 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1F10B6 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (C-Term) antibody
KEAP1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 65-160) antibody
KEAP1 适用: 人, 小鼠, 大鼠, Pig, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 327-624) antibody
KEAP1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 1-286) antibody
KEAP1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 41-53) antibody
Verified KEAP1 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibody
KD Validated KEAP1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB495 unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Ni, Wang, Qiu, Pang, Song, Guo: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." in: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).

Deng, Zhu, Mi, Xu, Jiao, Li, Xu, Liu, Xu: "Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1-Nrf2-ARE signaling pathway in the striatum of mice." in: Neurotoxicity research, Vol. 27, Issue 2, pp. 156-71, (2015) (PubMed).
抗原

KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

别名

KEAP1

背景

Synonyms: Kelch-like ECH-associated protein 1,Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19,KEAP1,INRF2, KIAA0132, KLHL19,
Tissue Specificity: Broadly expressed, with highest levels in skeletal muscle. .
Background: KEAP1 (KELCH-LIKE ECH-ASSOCIATED PROTEIN 1), is a protein that in humans is encoded by the Keap1 gene. The KIAA0132 gene is mapped on 19p13.2. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

分子量

66 kDa

基因ID

9817

UniProt

Q14145

途径

Maintenance of Protein Location