FOXP3 抗体 (Forkhead Box P3) (AA 321-337)

Details for Product anti-FOXP3 Antibody No. ABIN3043158, 供应商: Log in to see
抗原
  • foxp3
  • FOXP3
  • AIID
  • DIETER
  • IPEX
  • PIDX
  • XPID
  • JM2
  • scurfin
  • sf
  • RGD1562112
  • forkhead box P3
  • forkhead box P3a
  • forkhead box P3 L homeolog
  • FOXP3
  • foxp3a
  • foxp3
  • foxp3.L
  • Foxp3
抗原表位
AA 321-337, Middle Region
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适用

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宿主

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克隆类型
多克隆
标记
This FOXP3 antibody is un-conjugated
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应用范围
Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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原理 Rabbit IgG polyclonal antibody for Forkhead box protein P3(FOXP3) detection. Tested with WB in Human.
免疫原 A synthetic peptide corresponding to a sequence in the middle region of human FOXP3(321-337aa FPEFLHNMDYFKFHNMR), different from the related mouse sequence by two amino acids.
序列 FPEFLHNMDY FKFHNMR
亚型 IgG
交叉反应 (详细) No cross reactivity with other proteins.
产品特性 Rabbit IgG polyclonal antibody for Forkhead box protein P3(FOXP3) detection. Tested with WB in Human.
Gene Name: forkhead box P3
Protein Name: Forkhead box protein P3
纯化方法 Immunogen affinity purified.
别名 FOXP3 (FOXP3 Antibody 摘要)
背景 FOXP3(forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome(specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.

Synonyms: AIID antibody|DIETER antibody|Forkhead box P3 antibody|Forkhead box protein P3 antibody|foxp3 antibody|FOXP3_HUMAN antibody|FOXP3delta7 antibody|Immune dysregulation polyendocrinopathy enteropathy X linked antibody|immune dysregulation, polyendocrinopathy, enteropathy, X-linked antibody|Immunodeficiency polyendocrinopathy enteropathy X linked antibody|IPEX antibody|JM2 antibody|MGC141961 antibody|MGC141963 antibody|mmunodeficiency, polyendocrinopathy, enteropathy, X-linked antibody|OTTHUMP00000025832 antibody|OTTHUMP00000025833 antibody|OTTHUMP00000226737 antibody|PIDX antibody|SCURFIN antibody|XPID antibody
途径 Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
应用备注 WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制 仅限研究用
状态 Lyophilized
溶解方式 Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
浓度 500 μg/mL
缓冲液 Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
储存液 Thimerosal (Merthiolate), Sodium azide
注意事项 This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for anti-Forkhead Box P3 (FOXP3) (AA 321-337), (Middle Region) antibody (ABIN3043158) Anti-FOXP3 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: SGC Cell Lysate
有引用在: Li, Ren, Wang, Gu, Hu, Ren, Hong, Wu, Liu, Li: "T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease." in: International immunopharmacology, Vol. 18, Issue 2, pp. 244-8, 2014 (PubMed).

Wang, Dai, Dong, Sun, Song, Guo, Zhu, Wang, Zhang: "The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice." in: PLoS ONE, Vol. 9, Issue 1, pp. e87787, 2014 (PubMed).

Gai, Li, Song, Lei, Yang: "In situ analysis of FOXP3(+) regulatory T cells and myeloid dendritic cells in human colorectal cancer tissue and tumor-draining lymph node." in: Biomedical reports, Vol. 1, Issue 2, pp. 207-212, 2014 (PubMed).

Hu, Li, Maskey, Xu, Peng, Wang, Li, Yang: "Decreased intratumoral Foxp3 Tregs and increased dendritic cell density by neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer." in: International journal of clinical and experimental pathology, Vol. 7, Issue 8, pp. 4685-94, 2014 (PubMed).

Fu, Li, Yang, Gai, Jia, Lei, Li: "FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape." in: Acta histochemica, Vol. 115, Issue 2, pp. 151-7, 2013 (PubMed).

Gai, Song, Li, Lei, Yang: "Potential role of plasmacytoid dendritic cells for FOXP3+ regulatory T cell development in human colorectal cancer and tumor draining lymph node." in: Pathology, research and practice, Vol. 209, Issue 12, pp. 774-8, 2013 (PubMed).