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Kallikrein 5 抗体 (C-Term)

This anti-Kallikrein 5 antibody is a 兔 多克隆 antibody detecting Kallikrein 5 in WB 和 IHC. Suitable for 小鼠 和 大鼠.
产品编号 ABIN3043138
发货至: 中国

Quick Overview for Kallikrein 5 抗体 (C-Term) (ABIN3043138)

抗原

See all Kallikrein 5 (KLK5) 抗体
Kallikrein 5 (KLK5)

适用

  • 33
  • 16
  • 4
小鼠, 大鼠

宿主

  • 30
  • 8
  • 1

克隆类型

  • 30
  • 9
多克隆

标记

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  • 2
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This Kallikrein 5 antibody is un-conjugated

应用范围

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  • 13
  • 12
  • 6
  • 6
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 6
    • 3
    • 2
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    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
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    • 1
    AA 278-293, C-Term

    原理

    Anti-Kallikrein 5/KLK5 Antibody Picoband®

    序列

    NLCEFVKWIK DTMNSN

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Kallikrein 5/KLK5 Antibody (ABIN3043138). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 5, different from the related rat sequence by three amino acids.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Mouse
    1. Brattsand, M., Egelrud, T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274: 30033-30040, 1999. 2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 3. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Kallikrein 5 (KLK5)

    别名

    KLK5

    背景

    Synonyms: Kallikrein 1-related peptidase b5 ,Kallikrein related-peptidase 5 ,Klk5 ,

    Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells, isoform beta-3C is specifically expressed in prostate and testis.

    Background: KLK5 (Kallikrein-related peptidase 5), formerly known as stratum corneum tryptic enzyme (SCTE) or KLKL2, is a serine protease expressed in the epidermis. The KLK5 gene is one of the fifteen kallikrein subfamily members which is located on 19q13.41. KLK5 has been suggested to regulate cell shedding in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. The KLK5 gene contains 5 coding exons spanning 9.3. KLK5 expression is upregulated in a breast cancer cell line in the presence of estrogens and progestins and is associated with more aggressive forms of epithelial ovarian carcinoma.

    Sequence Similarities: Belongs to the integrin beta chain family.

    分子量

    29 kDa

    UniProt

    Q9D140

    途径

    Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
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