SPTLC1 抗体 (Middle Region)
Quick Overview for SPTLC1 抗体 (Middle Region) (ABIN3043056)
抗原
See all SPTLC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 138-154, Middle Region
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原理
- Anti-Serine palmitoyltransferase 1 SPTLC1 Antibody Picoband®
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序列
- FYGTFDVHLD LEDRLAK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Serine palmitoyltransferase 1 SPTLC1 Antibody (ABIN3043056). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human SPTLC1.
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亚型
- IgG
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anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (C-Term) antibody
SPTLC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 143-473) antibodySPTLC1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 37-310) antibodySPTLC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 43-143) antibodySPTLC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D11 unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 254-303) antibodySPTLC1 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibodySPTLC1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 马, 斑马鱼, 犬, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 216-265) antibodySPTLC1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 马, 斑马鱼, 猴, Hamster, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (AA 405-437), (C-Term) antibodySPTLC1 适用: 人 WB 宿主: 兔 Polyclonal RB4727 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
1. Dawkins, J. L., Hulme, D. J., Brahmbhatt, S. B., Auer-Grumbach, M., Nicholson, G. A.Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I.Nature Genet. 27: 309-312, 2001. 2. McCampbell, A., Truong, D., Broom, D. C., Allchorne, A., Gable, K., Cutler, R. G., Mattson, M. P., Woolf, C. J., Frosch, M. P., Harmon, J. M., Dunn, T. M., Brown, R. H., Jr.Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.Hum. Molec. Genet. 14: 3507-3521, 2005. 3. Verhoeven, K., Coen, K., De Vriendt, E., Jacobs, A., Van Gerwen, V., Smouts, I., Pou-Serradell, A., Martin, J.-J., Timmerman, V., De Jonghe, P.SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I.Neurology 62: 1001-1002, 2004. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
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别名
- SPTLC1
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背景
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Synonyms: Serine palmitoyltransferase 1,2.3.1.50,Long chain base biosynthesis protein 1,LCB 1,Serine-palmitoyl-CoA transferase 1,SPT 1,SPT1,SPTLC1,LCB1,
Tissue Specificity: Widely expressed. Not detected in small intestine. .
Background: SPTLC1 (Serine palmitoyltransferase, long chain base subunit 1), also known as SPT1, LCB1, is a protein which in humans is encoded by the SPTLC1 gene. Dawkins et al. (2001)noted that the SPTLC1 gene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
Sequence Similarities: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
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分子量
- 56 kDa
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UniProt
- O15269
抗原
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