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HMGB4 抗体 (N-Term)

This anti-HMGB4 antibody is a 兔 多克隆 antibody detecting HMGB4 in WB. Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN3043021
发货至: 中国

Quick Overview for HMGB4 抗体 (N-Term) (ABIN3043021)

抗原

See all HMGB4 抗体
HMGB4 (High Mobility Group Box 4 (HMGB4))

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

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多克隆

标记

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This HMGB4 antibody is un-conjugated

应用范围

  • 41
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Western Blotting (WB)
  • 抗原表位

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    AA 24-41, N-Term

    原理

    Anti-High mobility group protein B4 HMGB4 Antibody Picoband®

    序列

    RNKFKEQQPN TYVGFKEF

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-High mobility group protein B4 HMGB4 Antibody (ABIN3043021). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human HMGB4, different from the related mouse and rat sequences by one amino acid.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Phosphorylation of maize and Arabidopsis HMGB proteins by protein kinase CK2alpha.Stemmer C, Leeming DJ, Franssen L, Grimm R, Grasser KD. Institute of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK-9000 Aalborg, Denmark.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Rouhiainen, Zhao, Vanttola, Qian, Kulesskiy, Kuja-Panula, Gransalke, Grönholm, Unni, Meistrich, Tian, Auvinen, Rauvala: "HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation." in: Scientific reports, Vol. 6, pp. 32960, (2018) (PubMed).

    Zhao, Xue, Wang: "HMGB1, TGF-β and NF-κB are associated with chronic allograft nephropathy." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 6138-6146, (2017) (PubMed).

  • 抗原

    HMGB4 (High Mobility Group Box 4 (HMGB4))

    别名

    HMGB4

    背景

    Synonyms: High mobility group protein B4,HMGB4,

    Tissue Specificity: Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .

    Background: HMGB4 is HMG2 like, isoform 2, high-mobility group box 4. This gene can be found on Chromosome 1. HMGB4 contains two HMG-box regions, which is found in a variety of eukaryotic chromosomal proteins and transcription. HMGB proteins are phosphorylated to various extents reveals that the existence of differentially modified forms increases the number of distinct HMGB protein variants in plant chromatin that may be adapted to certain functions.

    Sequence Similarities: Belongs to the HMGB family.

    分子量

    23 kDa
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