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Patched 2 抗体 (C-Term)

This anti-Patched 2 antibody is a 兔 多克隆 antibody detecting Patched 2 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN3043014
发货至: 中国

Quick Overview for Patched 2 抗体 (C-Term) (ABIN3043014)

抗原

See all Patched 2 (PTCH2) 抗体
Patched 2 (PTCH2)

适用

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人, 小鼠

宿主

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克隆类型

  • 15
  • 1
多克隆

标记

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This Patched 2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 885-901, C-Term

    原理

    Anti-PTCH2 Antibody Picoband®

    序列

    WLHDKYDTTG ENLRIPP

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-PTCH2 Antibody (ABIN3043014). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2, different from the related mouse sequence by one amino acid.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse
    1. Nieuwenhuis, E., Motoyama, J., Barnfield, P. C., Yoshikawa, Y., Zhang, X., Mo, R., Crackower, M. A., Hui, C. Mice with a targeted mutation of Patched 2 are viable but develop alopecia and epidermal hyperplasia. Molec. Cell. Biol. 26: 6609-6622, 2006.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Patched 2 (PTCH2)

    别名

    PTCH2

    背景

    Synonyms: Protein patched homolog 2;PTC2;PTCH2;UNQ560/PRO1121/PRO57079;

    Tissue Specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .

    Background: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling.

    Sequence Similarities: Belongs to the patched family.

    分子量

    50 kDa

    UniProt

    Q9Y6C5

    途径

    Hedgehog Signaling
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